Volume 135, Issue 6, Pages e2 (December 2008)

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Volume 135, Issue 6, Pages 1961-1971.e2 (December 2008) Clinical Correlates of Histopathology in Pediatric Nonalcoholic Steatohepatitis Heather M. Patton, Joel E. Lavine, Mark L. Van Natta, Jeffrey B. Schwimmer, David Kleiner, Jean Molleston Gastroenterology Volume 135, Issue 6, Pages 1961-1971.e2 (December 2008) DOI: 10.1053/j.gastro.2008.08.050 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Box plot of AST and ALT values according to NAFLD pattern, fibrosis stage, and NAS. Gastroenterology 2008 135, 1961-1971.e2DOI: (10.1053/j.gastro.2008.08.050) Copyright © 2008 AGA Institute Terms and Conditions

Supplementary Figure 1 Comparison between a case of steatohepatitis with zone 3 injury pattern and the zone 1 steatosis and fibrosis pattern observed in some children. (A) Steatohepatitis showing prominent ballooning injury with Mallory body formation in the center of the field. A small, normal-appearing portal area is present nearby (H&E, 200×). (B) A liver biopsy showing periportal zone 1 macrovesicular steatosis adjacent to a fibrotic portal area. The zone 3 region and the central vein at the top of the photograph are unremarkable. There was portal–portal bridging fibrosis elsewhere in the biopsy specimen, but no perisinusoidal fibrosis. Gastroenterology 2008 135, 1961-1971.e2DOI: (10.1053/j.gastro.2008.08.050) Copyright © 2008 AGA Institute Terms and Conditions