How to Survive Aneuploidy Bulent Cetin, Don W. Cleveland  Cell  Volume 143, Issue 1, Pages 27-29 (October 2010) DOI: 10.1016/j.cell.2010.09.030 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Aneuploidy Induces Proteotoxic Stress (Top) An extra copy of an individual yeast chromosome, or disomy, causes imbalanced expression of the proteins encoded on that chromosome. Adding an inhibitor of protein synthesis, such as G418 (Geneticin), increases the errors in translation and enhances the proteotoxic stress. This stress reduces fitness and inhibits cell growth primarily during the G1 phase of the cell cycle. (Bottom) Suppressers of proteotoxic stress, including mutations in components of the ubiquitin/proteasome pathway, can ameliorate the proteomic imbalance and restore fitness (Torres et al., 2010). For example, disrupting the deubiquitinase UPB6 can increase the growth rate of aneuploid cells by triggering more rapid protein degradation by the proteasome. Cell 2010 143, 27-29DOI: (10.1016/j.cell.2010.09.030) Copyright © 2010 Elsevier Inc. Terms and Conditions