Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue  Franklin Rosenfeldt, MD,

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Presentation transcript:

Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue  Franklin Rosenfeldt, MD, FRACS, Silvana Marasco, FRACS, William Lyon, MBBS, Michelle Wowk, BSc(Hons), Freya Sheeran, BA, BSc(Hons), Michael Bailey, MSc(Stats), Donald Esmore, FRACS, Bruce Davis, FRACS, Adrian Pick, FRACS, Mark Rabinov, PhD, FRACS, Julian Smith, MSurg, FRACS, Phillip Nagley, PhD, DSc, Salvatore Pepe, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 129, Issue 1, Pages 25-32 (January 2005) DOI: 10.1016/j.jtcvs.2004.03.034

Figure 1 A, Coupled O2 consumption state III respiration in isolated human mitochondria during oxidation of pyruvate (2.5 mmol/L) plus malate (0.5 mmol/L) at 37°C. B, The efficiency of energy production expressed as a stochiometric ratio of ADP consumed during ATP production per atom of oxygen consumed. C, The concentration of the lipid peroxidation product MDA in isolated human mitochondria. The Journal of Thoracic and Cardiovascular Surgery 2005 129, 25-32DOI: (10.1016/j.jtcvs.2004.03.034)

Figure 2 Contractile recovery of developed force in atrial pectinate trabeculae after 30 minutes of hypoxia. The Journal of Thoracic and Cardiovascular Surgery 2005 129, 25-32DOI: (10.1016/j.jtcvs.2004.03.034)