Erythropoietin, progenitors, and repair

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Erythropoietin, progenitors, and repair Z. Aydin, J. Duijs, I.M. Bajema, A.J. van Zonneveld, T.J. Rabelink Kidney International Volume 72, Pages S16-S20 (November 2007) DOI: 10.1038/sj.ki.5002483 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Illustration of ischemia–reperfusion injury and the cytoprotective effects of erythropoietin. Vascular injury to the kidney was applied by clamping the renal artery for 45 min in Lewis rats (N=12). At day 2, there was extensive tubular injury (periodic acid Schiff staining, original magnification × 200 (a), Leukocyte infiltration (CD45 staining, original magnification × 100 (b) and primitive angiogenesis as a defense against hypoxia (c-Kit staining, original magnification × 100). (c) Pretreatment with 2000 U of EPO subcutaneously resulted in a marked decrease in tubular injury (histological injury score from 3 to 1 (median), periodic acid Schiff staining, original magnification × 200). (d) It also prevented the decrease in renal function induced by ischemia–reperfusion injury (at day 1, 86 vs 127 μmol/l; at day 2, 66 vs 150 μmol/l, P< 0.05). Pretreatment with EPO was associated with a strong reduction in endothelial–leukocyte interaction, as exemplified by the reduction in CD45 staining (in the cortex, 264 724 vs 364 512 pixels/area; in the medulla, 480 935 vs 793 037 pixels/area, P< 0.05). Kidney International 2007 72, S16-S20DOI: (10.1038/sj.ki.5002483) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Effect of EPO on progenitor lineage mobilization and differentiation. Kidney International 2007 72, S16-S20DOI: (10.1038/sj.ki.5002483) Copyright © 2007 International Society of Nephrology Terms and Conditions