Dara G. Torgerson, Daniel Capurso, Rasika A. Mathias, Penelope E

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Resequencing Candidate Genes Implicates Rare Variants in Asthma Susceptibility Dara G. Torgerson, Daniel Capurso, Rasika A. Mathias, Penelope E. Graves, Ryan D. Hernandez, Terri H. Beaty, Eugene R. Bleecker, Benjamin A. Raby, Deborah A. Meyers, Kathleen C. Barnes, Scott T. Weiss, Fernando D. Martinez, Dan L. Nicolae, Carole Ober The American Journal of Human Genetics Volume 90, Issue 2, Pages 273-281 (February 2012) DOI: 10.1016/j.ajhg.2012.01.008 Copyright © 2012 The American Society of Human Genetics Terms and Conditions

Figure 1 Combined Site-Frequency Spectrum of European American and African American Cases and Controls Site-frequency spectrum of 1,225 variants identified through the resequencing of coding exons and flanking noncoding regions of nine candidate asthma-associated genes in 450 cases (108 European American and 342 African American) and 515 controls (248 European American and 267 African American). We resampled a total of 100 chromosomes in each of the European American and African American cases and controls to account for missing data and differences in sample size. Derived alleles were pooled for variants with >2 alleles; we used data from the chimpanzee to infer ancestral states. Plots for individual genes are shown in Figure S1. The American Journal of Human Genetics 2012 90, 273-281DOI: (10.1016/j.ajhg.2012.01.008) Copyright © 2012 The American Society of Human Genetics Terms and Conditions