Association of smooth muscle cell phenotypic modulation with extracellular matrix alterations during neointima formation in rabbit vein grafts Wei-da.

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Association of smooth muscle cell phenotypic modulation with extracellular matrix alterations during neointima formation in rabbit vein grafts Wei-da Zhang, MD, Hong-zhi Bai, MD, Yoshiki Sawa, MD, Tomoyuki Yamakawa, MD, Keishi Kadoba, MD, Kazuhiro Taniguchi, MD, Junichi Masuda, MD, Jun Ogata, MD, Ryota Shirakura, MD, Hikaru Matsuda MD Journal of Vascular Surgery Volume 30, Issue 1, Pages 169-183 (July 1999) DOI: 10.1016/S0741-5214(99)70189-8 Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 1 Color photomicrographs show structures of tributary of external jugular vein before transplantation (control vein). Adjacent sections of paraffin-embedded tissue were stained with Masson trichrome (A) or elastica van Gieson's solution (B) or immunohistochemically for α-actin (C), and those from frozen tissue were stained for SM2 (D), SMemb (E), and nonimmunized IgG (F). Bar in panel F, 20 μm (applies to all panels). Journal of Vascular Surgery 1999 30, 169-183DOI: (10.1016/S0741-5214(99)70189-8) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 2 Temporal changes of intimal thickening expressed as intimal area (A) and cell proliferation expressed as proliferating nuclear cell antigen (PCNA) index and cell density in the intima (B) after transplantation. Each point is mean ± SD of measurements of 10 sections in vein grafts dissected at corresponding time points. Statistically significant differences are shown as *P < .05, compared with the values at previous time points as determined with analysis of variance and post hoc Fisher exact test. @ indicates no significant difference. Journal of Vascular Surgery 1999 30, 169-183DOI: (10.1016/S0741-5214(99)70189-8) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 3 Color photomicrographs showing vein grafts transplanted into carotid arteries at days 4 (A,B), 7 (C,D) and 14 (E,F) and at 2 months (G,H) and 6 months (I,J) after surgery. Adjacent sections from each paraffin-embedded tissue were stained with Masson trichrome (A,C,E,G,I), and elastica van Gieson's solution (B,D,F,H,J). Arrowheads indicate internal elastic lamina. Bar in panel J, 20 μm (applies to all panels). Journal of Vascular Surgery 1999 30, 169-183DOI: (10.1016/S0741-5214(99)70189-8) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 4 Color photomicrographs showing vein grafts transplanted into carotid arteries at days 4 (A,B), 7 (C,D) and 14 (E,F), and at 2 months (G,H) and 6 months (I,J,K) after surgery. Adjacent sections from each paraffin-embedded tissue were stained immunohistochemically for α-actin (A,C,E,G,I), proliferating cell nuclear antigen (B,D,F,H,J), and nonimmunized IgG (K). Dashed line in I indicates the internal elastic lamina. Bar in panel K, 20 μm (applies to all panels). Journal of Vascular Surgery 1999 30, 169-183DOI: (10.1016/S0741-5214(99)70189-8) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 5 Photomicrographs showing immunohistochemical staining for myosin heavy chain isoforms, SM2 (A,C,E,G,I) and SMemb (B,D,F,H,I), in frozen sections of vein grafts dissected at days 4 (A,B), 7 (C,D), and 14 (E,F) and at 2 months (G,H) and 6 months (I,J) after transplantation. Bar in panel J, 20 μm (applies to all panels). Journal of Vascular Surgery 1999 30, 169-183DOI: (10.1016/S0741-5214(99)70189-8) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 6 Photomicrographs showing immunohistochemical staining for extracellular matrix components, type I collagen (A,D,G,J), heparan sulfate proteoglycan (B,E,H,K), and decorin (C,F,I,L) in paraffin sections of vein grafts dissected at days 7 (A-C) and 14 (D-F) and at 2 months (G-I) and 6 months (J-L) after transplantation. Areas marked with * indicate hypocellular region localized deep in the intima. Bar in panel K, 20 μm (applies to all panels). Journal of Vascular Surgery 1999 30, 169-183DOI: (10.1016/S0741-5214(99)70189-8) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions