Human HFpEF is associated with impaired cardiac myofibril relaxation

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Fig. 6 Human HFpEF is associated with impaired cardiac myofibril relaxation. Human HFpEF is associated with impaired cardiac myofibril relaxation. (A) Representative relaxation traces of myofibrils from nonfailing donor heart (n = 1) and hearts from two individuals with HFpEF superimposed on identical time scale. Linear phase duration (tRel, slow) (B) and slope of the linear phase relaxation (kRel, slow) (C) from myofibrils from RCM patients and control nonfailing donor heart. Exponential phase relaxation (kRel, fast) (D) and maximal tension generation (E) from RCM patients and nonfailing donor heart. Data are mean + SEM and were compared by one-way ANOVA with Newman-Keuls post-test. *P < 0.05 versus nonfailing controls. n = 5 nonfailing donors (7 to 16 myofibril bundles per donor). For RCM patient #1, 16 myofibril bundles were analyzed, and for RCM patient #2, 12 myofibril bundles were analyzed. Mark Y. Jeong et al., Sci Transl Med 2018;10:eaao0144 Published by AAAS