The association between anti-Müllerian hormone and IVF pregnancy outcomes is influenced by age  Jeff G. Wang, Nataki C. Douglas, Gary S. Nakhuda, Janet M. Choi, Susanna J. Park, Melvin H. Thornton, Michael M. Guarnaccia, Mark V. Sauer  Reproductive BioMedicine Online  Volume 21, Issue 6, Pages 757-761 (December 2010) DOI: 10.1016/j.rbmo.2010.06.041 Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 (A) The relationship between IVF clinical pregnancy rates per initiated cycle and serum anti-Müllerian hormone (AMH) tertiles stratified by age. For women aged <34years, the only significant difference in pregnancy rate was between that of women in the highest and the lowest tertiles (P<0.02). For women aged 34–37years, the clinical pregnancy rates demonstrated a significant positive linear relationship with serum AMH concentrations (P<0.01). This relationship was also observed for women 38–41 (P<0.01). For women aged ⩾42years with AMH ⩽0.29ng/ml, the clinical pregnancy rate was significantly lower than those of the middle and higher quartiles (P<0.004 and P<0.001 respectively). The clinical pregnancy rates for women in the middle and highest tertiles were not significantly different. (B) Cycle cancellation risks for women with AMH concentrations in the lowest tertile were significantly higher than those of women whose AMH concentrations were in the higher tertiles for all age groups (all P<0.01). (C) Clinical pregnancy rates per retrieval after excluding the cycles that were cancelled due to poor response during ovarian stimulation did not differ significantly across all three AMH tertiles for women aged <34years. For women aged 34–37years, the only significant difference in clinical pregnancy rate was between those of the highest and the lowest tertiles (P<0.005). For women aged 38–41years, the clinical pregnancy rate in the highest tertile was significantly greater than those of the middle (P<0.02) and lowest tertiles (P<0.001). For women aged ⩾42years, clinical pregnancy rate in the lowest tertile was significantly lower than those of the middle (P<0.01) and highest (P<0.01) tertiles. However, women having AMH in the highest tertile did not have a greater chance of pregnancy compared with those of women in the middle tertile. (D) The live birth rates per embryo transfer did not differ significantly across all three AMH tertiles for women aged <34years. For women aged 34–37years, the live birth rate in women with AMH in the lowest tertile was significantly lower than those of the middle (P<0.05) and highest tertiles (P<0.05). For women aged 38–41years, the live birth rates for women in the low, middle and high AMH tertiles, respectively, were not statistically significantly different. For women aged ⩾42years, significantly more live births were observed in the highest AMH compared with the lowest. ∗P<0.05 compared with the highest tertile; †P<0.05 compared with the middle tertile. Reproductive BioMedicine Online 2010 21, 757-761DOI: (10.1016/j.rbmo.2010.06.041) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 (A) The relationship between IVF clinical pregnancy rates per initiated cycle and serum anti-Müllerian hormone (AMH) tertiles stratified by age. For women aged <34years, the only significant difference in pregnancy rate was between that of women in the highest and the lowest tertiles (P<0.02). For women aged 34–37years, the clinical pregnancy rates demonstrated a significant positive linear relationship with serum AMH concentrations (P<0.01). This relationship was also observed for women 38–41 (P<0.01). For women aged ⩾42years with AMH ⩽0.29ng/ml, the clinical pregnancy rate was significantly lower than those of the middle and higher quartiles (P<0.004 and P<0.001 respectively). The clinical pregnancy rates for women in the middle and highest tertiles were not significantly different. (B) Cycle cancellation risks for women with AMH concentrations in the lowest tertile were significantly higher than those of women whose AMH concentrations were in the higher tertiles for all age groups (all P<0.01). (C) Clinical pregnancy rates per retrieval after excluding the cycles that were cancelled due to poor response during ovarian stimulation did not differ significantly across all three AMH tertiles for women aged <34years. For women aged 34–37years, the only significant difference in clinical pregnancy rate was between those of the highest and the lowest tertiles (P<0.005). For women aged 38–41years, the clinical pregnancy rate in the highest tertile was significantly greater than those of the middle (P<0.02) and lowest tertiles (P<0.001). For women aged ⩾42years, clinical pregnancy rate in the lowest tertile was significantly lower than those of the middle (P<0.01) and highest (P<0.01) tertiles. However, women having AMH in the highest tertile did not have a greater chance of pregnancy compared with those of women in the middle tertile. (D) The live birth rates per embryo transfer did not differ significantly across all three AMH tertiles for women aged <34years. For women aged 34–37years, the live birth rate in women with AMH in the lowest tertile was significantly lower than those of the middle (P<0.05) and highest tertiles (P<0.05). For women aged 38–41years, the live birth rates for women in the low, middle and high AMH tertiles, respectively, were not statistically significantly different. For women aged ⩾42years, significantly more live births were observed in the highest AMH compared with the lowest. ∗P<0.05 compared with the highest tertile; †P<0.05 compared with the middle tertile. Reproductive BioMedicine Online 2010 21, 757-761DOI: (10.1016/j.rbmo.2010.06.041) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions