Cholecalciferol treatment restores the relaxant responses of spontaneously hypertensive rat arteries to bradykinin Antonio C.R Borges, Teresa Feres,

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Cholecalciferol treatment restores the relaxant responses of spontaneously hypertensive rat arteries to bradykinin Antonio C.R Borges, Teresa Feres, Lucia M Vianna, Therezinha B Paiva Pathophysiology Volume 8, Issue 4, Pages 263-268 (August 2002) DOI: 10.1016/S0928-4680(02)00036-6

Fig. 1 Concentration–response curves for the vasorelaxation induced by BK in the perfused mesenteric vascular bed from untreated (NWR, WKY, SHR) and cholecalciferol-treated (NWR.D3, WKY.D3, SHR.D3) rats. The relaxations are expressed as percentages of the initial tone maintained by perfusion with 1–3 μmol l−1 noradrenaline. Symbols and vertical lines indicate means and S.E.M., n=7–10 in each group. *P<0.05 WKY, WKY.D3 versus NWR, NWR.D3, SHR.D3 (Newman–Keuls test). **P<0.05 SHR versus NWR, NWR.D3, SHR.D3 (Newman–Keuls test). Pathophysiology 2002 8, 263-268DOI: (10.1016/S0928-4680(02)00036-6)

Fig. 2 Concentration–response curves for the vasorelaxation induced by BK in the perfused mesenteric vascular bed from untreated (NWR, SHR) and cholecalciferol-treated (SHR.D3) rats in the absence and in the presence of apamin (Apa, 100 nmol l−1). The relaxations are expressed as percentages of the initial tone maintained by perfusion with 1–3 μmol l−1 noradrenaline. Symbols and vertical lines indicate means and S.E.M., n=7–10 in each group. *P<0.05 versus SHR, SHR.D3+Apa and NWR+Apa (Newman–Keuls test). †P<0.05 versus SHR (Newman–Keuls test), ‡P<0.05, ANOVA for repeated measurements. Pathophysiology 2002 8, 263-268DOI: (10.1016/S0928-4680(02)00036-6)

Fig. 3 Concentration–response curves for the relaxation induced by BK in the isolated endothelium-intact mesenteric arterial rings from control (NWR, SHR) and cholecalciferol-treated (SHR.D3) rats in the presence of captopril (1 μmol l−1). The relaxations are expressed as percentages of the initial tone produced by 3 μmol l−1 noradrenaline. Symbols and vertical lines indicate means and S.E.M., n=6–15 in each group. *P<0.05 versus other groups (Newman–Keuls test). Pathophysiology 2002 8, 263-268DOI: (10.1016/S0928-4680(02)00036-6)

Fig. 4 Membrane potentials measured in smooth muscle cells of mesenteric artery rings with intact endothelium from control (NWR, SHR) and cholecalciferol-treated (SHR.D3) rats in the absence (RMP) and in the presence of captopril (CPT, 1 μmol L−1) plus 3 μmol l−1 noradrenaline (NA) or NA plus bradykinin (BK, 1 μmol l−1). For each mesenteric ring obtained from individual rats (the number of which is shown in parenthesis below the bars), six to ten cells were impaled and the averages of the respective measurements were used to obtain the means and S.E.M. *P<0.05 versus respective measurements in NWR and SHR.D3. †P<0.05 versus respective RMP. ‡P<0.05 versus NA (Newman–Keuls test). Pathophysiology 2002 8, 263-268DOI: (10.1016/S0928-4680(02)00036-6)