Richard J. Novick, MDa, Andrea A. Gilpin, MSca,b, Kenneth E

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Presentation transcript:

Mitigation of injury in canine lung grafts by exogenous surfactant therapy Richard J. Novick, MDa, Andrea A. Gilpin, MSca,b, Kenneth E. Gehman, MDa, Imtiaz S. Ali, MDa, Ruud A.W. Veldhuizen, PhDc, Jenifer Duplan, AHTa, Lynn Denning, AHTa, Fred Possmayer, PhDd, David Bjarneson, PhDe, James F. Lewis, MDc The Journal of Thoracic and Cardiovascular Surgery Volume 113, Issue 2, Pages 342-353 (February 1997) DOI: 10.1016/S0022-5223(97)70332-5 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Po2/Fio2 ratio (mean plus or minus standard error of the mean [SEM]) in the two experimental groups during 8 hours of high-volume ventilation in donor animals. Differences between groups, where significant, are stated in the text. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 342-353DOI: (10.1016/S0022-5223(97)70332-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Changes in values of Pco2 and peak inspired pressure (PIP) during 8 hours of high-volume ventilation in donor animals (mean plus or minus standard error of the mean [SEM]). There were no significant differences in Pco2 and PIP values between groups. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 342-353DOI: (10.1016/S0022-5223(97)70332-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Po2/Fio2 ratio (mean plus or minus standard error of the mean [SEM]) in the two experimental groups during reperfusion. Differences between groups, where significant, are stated in the text. Baseline, Pretransplantation Po2/Fio2 value. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 342-353DOI: (10.1016/S0022-5223(97)70332-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Changes in values of Pco2 and peak inspired pressure (PIP) during reperfusion (mean plus or minus standard error of the mean [SEM]). Differences between groups, where significant, are stated in the text. Baseline, Pretransplantation Pco2 and peak inspired pressure values. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 342-353DOI: (10.1016/S0022-5223(97)70332-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 The ratio of surfactant small aggregates to large aggregates in stored donor right lungs, in the native right lungs of recipient animals, and in transplanted left lung grafts after 6 hours of reperfusion. Differences between groups, where significant, are stated in the text. SEM, Standard error of the mean. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 342-353DOI: (10.1016/S0022-5223(97)70332-5) Copyright © 1997 Mosby, Inc. Terms and Conditions