Robert A. McCready, M. D. , Margaret A. Price, B. S. , Richard J

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Presentation transcript:

Failure of antiplatelet therapy with ibuprofen (Motrin) to prevent neointimal fibrous hyperplasia Robert A. McCready, M.D., Margaret A. Price, B.S., Richard J. Kryscio, Ph.D., Gordon L. Hyde, M.D., Sally S. Mattingly, M.D., Ward O. Griffen, M.D., Ph.D. Journal of Vascular Surgery Volume 2, Issue 1, Pages 205-213 (January 1985) DOI: 10.1016/0741-5214(85)90190-9 Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Light microscopic picture demonstrating disruption of internal elastic lamina with significant intimal hyperplasia. A, Lumen; B, anastomotic intimal hyperplasia; C, PTFE graft; D, internal elastic membrane; E, native artery. (Verhoeff's elastin stain; original magnification × 25.) Journal of Vascular Surgery 1985 2, 205-213DOI: (10.1016/0741-5214(85)90190-9) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Light microscopic section demonstrating smooth muscle cell hyperplasia extending from host artery (not shown) over graft luminal surface. A, Lumen; B, smooth muscle cells; C, PTFE graft demonstrating excellent tissue ingrowth into graft matrix. (Hematoxylin-eosin stain; original magnification × 50.) Journal of Vascular Surgery 1985 2, 205-213DOI: (10.1016/0741-5214(85)90190-9) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Light microscopic section demonstrating marked intimal hyperplasia. A, Lumen; B, smooth muscle cell hyperplasia; C, PTFE graft. (Hematoxylin-eosin stain; original magnification × 50.) Journal of Vascular Surgery 1985 2, 205-213DOI: (10.1016/0741-5214(85)90190-9) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions