Direct Conversion Provides Old Neurons from Aged Donor’s Skin

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Presentation transcript:

Direct Conversion Provides Old Neurons from Aged Donor’s Skin Philipp Koch Cell Stem Cell Volume 17, Issue 6, Pages 637-638 (December 2015) DOI: 10.1016/j.stem.2015.11.009 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Fibroblasts from Young and Aged Donors Exhibit Differential and Age-Related Profiles During reprogramming, cells rejuvenate and iPSC-derived neurons are “young,” independent of the donor age. When converted directly from fibroblasts without going via pluripotency, neurons retain age-related traits of the donor cell population. Figure produced using Servier Medical Art (http://www.servier.com). Cell Stem Cell 2015 17, 637-638DOI: (10.1016/j.stem.2015.11.009) Copyright © 2015 Elsevier Inc. Terms and Conditions