Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma Yoichi Ohtaki, MD, Genichiro Ishii, MD, PhD, Kanji.

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Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma Yoichi Ohtaki, MD, Genichiro Ishii, MD, PhD, Kanji Nagai, MD, PhD, Satoshi Ashimine, MD, Takeshi Kuwata, MD, Tomoyuki Hishida, MD, PhD, Mitsuyo Nishimura, MD, PhD, Junji Yoshida, MD, PhD, Izumi Takeyoshi, MD, PhD, Atsushi Ochiai, MD, PhD Journal of Thoracic Oncology Volume 5, Issue 10, Pages 1507-1515 (October 2010) DOI: 10.1097/JTO.0b013e3181eba692 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Immunostaining of stromal CD68+ macrophages (A and B) and CD204+ macrophages (C and D). A, CD68 macrophages (low number), (B) CD68 macrophages (high number), (C) CD204 macrophages (low number), and (D) CD204 macrophages (high number). Journal of Thoracic Oncology 2010 5, 1507-1515DOI: (10.1097/JTO.0b013e3181eba692) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Distribution of CD68+ and CD204+ macrophages. A, Correlations between the distribution of CD68+ macrophages and CD204+ macrophages of each case are shown. The numbers of CD204+ macrophages were significantly correlated with the numbers of CD68+ macrophages (r2 = 0.5910, p < 0.001). B, The mean number of CD68-positive macrophages and CD204-positive macrophages was 30.6 ± 1.8 (median: 25, range: 0–120) and 24.8 ± 2.0 (median: 15, range: 0–143), respectively. Journal of Thoracic Oncology 2010 5, 1507-1515DOI: (10.1097/JTO.0b013e3181eba692) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Numbers of CD68+ macrophages (A) and CD204+ macrophages (B) in each histologically predominant subtype (bronchioloalveolar carcinoma [BAC], papillary, acinar, and solid). Journal of Thoracic Oncology 2010 5, 1507-1515DOI: (10.1097/JTO.0b013e3181eba692) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Kaplan-Meier analysis of overall survival. Kaplan-Meier analysis of overall survival according to the level of infiltration by CD68+ macrophages (A) and by CD204+ macrophages (B). Data were dichotomized at the median value for each parameter. Journal of Thoracic Oncology 2010 5, 1507-1515DOI: (10.1097/JTO.0b013e3181eba692) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 5 Correlations between the levels of expression of factors and numbers of CD204+ macrophages. A, The levels of expression shown are ratios of expression in cancer tissue to expression in noncancerous tissue. The ratios are expressed as means ± standard deviation. Expression of IL-10 (p = 0.0031) and MCP-1 (p = 0.0031) was significantly higher in the CD204high group (n = 9) than in the CD204low group (n = 9). The differences in expression of IL-6 (p = 0.122), IL-12a (p = 0.666), IL-12b (p = 0.436), M-CSF (p = 0.284), and IFN-gamma-. (p = 0.233) were not significant. B, Correlations between levels of IL-10 and MCP-1 expression (ratios of expression in cancer tissue to expression in noncancerous tissue) and the distribution of CD204+ macrophages of each case are shown. The numbers of CD204-positive macrophages were significantly correlated with the increases in the ratios of IL-10 expression (r2 = 0.580, p < 0.001) and MCP-1 expression (r2 = 0.641, p < 0.001). Journal of Thoracic Oncology 2010 5, 1507-1515DOI: (10.1097/JTO.0b013e3181eba692) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions