JAK1 Takes a FERM Hold of Type II Cytokine Receptors

Slides:

Advertisements

Similar presentations

Influence of Domain Interactions on Conformational Mobility of the Progesterone Receptor Detected by Hydrogen/Deuterium Exchange Mass Spectrometry Devrishi.

Advertisements

Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics Yongneng Yao, John Belcher,

Structure of the Hepatitis C Virus IRES Bound to the Human 80S Ribosome: Remodeling of the HCV IRES Daniel Boehringer, Rolf Thermann, Antje Ostareck-Lederer,

Recognizing Protein-Ligand Binding Sites by Global Structural Alignment and Local Geometry Refinement Ambrish Roy, Yang Zhang Structure Volume 20, Issue.

Biogenesis of Nascent High Density Lipoprotein Particles

XPF-ERCC1: On the Bubble

Biogenesis of Nascent High Density Lipoprotein Particles

Electrostatic Fasteners Hold the T Cell Receptor-CD3 Complex Together

Ross Alexander Robinson, Xin Lu, Edith Yvonne Jones, Christian Siebold

Deubiquitination of Lys63-Linkage by a CYLD UBP

RBR Ubiquitin Transfer: Not Simply an “Open” and “Closed” Case?

JAK's SOCS: A Mechanism of Inhibition

Volume 15, Issue 3, Pages (March 2007)

Volume 22, Issue 7, Pages (July 2014)

Amyloid Structures from Alzheimer’s Disease Patients

Blocking HIV-1 gp120 at the Phe43 Cavity: If the Extension Fits…

Multiple Motifs Compete for EB-Dependent Microtubule Plus End Binding

Deubiquitination of Lys63-Linkage by a CYLD UBP

Volume 25, Issue 8, Pages (August 2017)

An Uncommon Tail about the Common γ-Chain

Protein Kinase C Regulation: C1 Meets C-tail

The Architecture of Restriction Enzymes

Structure and Intrinsic Disorder in Protein Autoinhibition

JAK3 Specific Kinase Inhibitors: When Specificity Is Not Enough

Xiaojing He, Yi-Chun Kuo, Tyler J. Rosche, Xuewu Zhang Structure

A View into the Blind Spot: Solution NMR Provides New Insights into Signal Transduction Across the Lipid Bilayer Matthew E. Call, James J. Chou Structure

Expanding the PP2A Interactome by Defining a B56-Specific SLiM

Complex Energy Landscape of a Giant Repeat Protein

How to Grb2 a Gab Structure

Calcineurin Current Biology

From Shellfish Poisoning to Neuroscience

Multiple Motifs Compete for EB-Dependent Microtubule Plus End Binding

Volume 15, Issue 1, Pages (January 2007)

Structures of Minimal Catalytic Fragments of Topoisomerase V Reveals Conformational Changes Relevant for DNA Binding Rakhi Rajan, Bhupesh Taneja, Alfonso.

Volume 19, Issue 10, Pages (October 2011)

Ins and Outs of Kinase DFG Motifs

Ross Alexander Robinson, Xin Lu, Edith Yvonne Jones, Christian Siebold

Volume 20, Issue 10, Pages (October 2012)

Switching on BTK—One Domain at a Time

Volume 14, Issue 9, Pages (September 2006)

Seisuke Yamashita, Kozo Tomita Structure

HLA-F: A New Kid Licensed for Peptide Presentation

Asymmetric EM Reveals New Twists in Phage ϕ29 Biology

Volume 21, Issue 12, Pages (December 2013)

Volume 15, Issue 11, Pages (November 2007)

Volume 20, Issue 6, Pages (June 2012)

JAK/STAT Signalling: STAT Cannot Play with Ken and Barbie

Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self- Assembled Tetramer Yongheng Chen, Raja Dey, Lin Chen Structure Volume.

Amyloid Structures from Alzheimer’s Disease Patients

Recognition of the Regulatory Nascent Chain TnaC by the Ribosome

Crystal Structures of the BAR-PH and PTB Domains of Human APPL1

Fibronectin Structure: A New Piece of the Puzzle Emerges

Screening for a Diamond in the Rough

Reduced Curvature of Ligand-Binding Domain Free-Energy Surface Underlies Partial Agonism at NMDA Receptors Jian Dai, Huan-Xiang Zhou Structure Volume.

Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes Jan J. Palecek, Stephan Gruber Structure Volume.

Volume 17, Issue 8, Pages (August 2009)

Volume 24, Issue 6, Pages (June 2016)

Volume 21, Issue 7, Pages (July 2014)

Improving management of neonatal infections

Volume 17, Issue 1, Pages (January 2009)

Volume 26, Issue 6, Pages e3 (June 2018)

Volume 20, Issue 7, Pages (July 2012)

Volume 17, Issue 1, Pages (January 2009)

Volume 15, Issue 3, Pages (March 2007)

cGAS Dimerization Entangles DNA Recognition

Microbials for the production of monoclonal antibodies and antibody fragments Oliver Spadiut, Simona Capone, Florian Krainer, Anton Glieder, Christoph.

Yogesh K. Gupta, Deepak T. Nair, Robin P. Wharton, Aneel K. Aggarwal

Structural Switch of the γ Subunit in an Archaeal aIF2αγ Heterodimer

Volume 21, Issue 6, Pages (June 2013)

Volume 25, Issue 1, Pages (January 2017)

Presentation transcript:

JAK1 Takes a FERM Hold of Type II Cytokine Receptors Jeffrey J. Babon, Nicholas P.D. Liau, Nadia J. Kershaw Structure Volume 24, Issue 6, Pages 840-842 (June 2016) DOI: 10.1016/j.str.2016.05.007 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 A Model of the JAK:Receptor Interaction On the left, the structure of JAK1 bound to box1 from the IFNλ receptor (PDB: 5IXD (Ferrao et al., 2016)) is shown overlaid with the box2 motif from the IFNα receptor (PDB: 4PO6 (Wallweber et al., 2014)). The PxxLxF motif within box1 identified by Ferrao et al. (2016) is shown with the sidechains colored white. Although box1 and box2 occupy non-overlapping, nearly continuous binding sites, they have not yet both been observed in the one structure. On the right is a schematic of a full-length JAK/Receptor interaction. For clarity, only one receptor chain and associated JAK is shown. The boxed region corresponds to the structural model shown on the left. Structure 2016 24, 840-842DOI: (10.1016/j.str.2016.05.007) Copyright © 2016 Elsevier Ltd Terms and Conditions