Change from baseline in the severity of morning cough and severity of difficulty bringing up phlegm in the morning over the study period in the active-comparator study. Change from baseline in the severity of morning cough and severity of difficulty bringing up phlegm in the morning over the study period in the active-comparator study. Data are reported as LS mean+SE. Assessed on a 5-point scale: 0=‘no symptoms’ to 4=‘very severe symptoms’. *p<0.05, **p<0.01 vs placebo. LS, least squares. Lorcan McGarvey et al. BMJ Open Resp Res 2016;3:e000148 ©2016 by British Thoracic Society