Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Slides:



Advertisements
Similar presentations
High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.
Advertisements

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.
Identification of combination treatment–responsive effector/memory tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.
Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.
MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.
MP cells are generated from naïve cells in the periphery.
MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.
TPAD controller schematic and testing for WPC.
TPAD controller performance for three force components.
FIP200 maintains microRNA1198-5p expression via Ago2 in naïve T cells.
Cable-driven system diagram for structure matrix.
Three different types of transfer functions with a codomain of [0,1].
TPAD training protocol.
Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells. Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells.
Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.
Memory CD8+ T cells that become terminally differentiated by multiple antigen encounters lose core 2 O-glycan synthesis activity. Memory CD8+ T cells that.
Workspace comparison of Delta robots.
Protein sequence alignment of the NS3 helicase–encoding region of 63 flaviviruses demonstrates conservation of a KIR2DS2-binding peptide. Protein sequence.
Virus-specific T cell responses are detected in all MERS survivors.
VH usage of cross-reactive B cells induced by H5N1 or H7N9 vaccination
Human cells produce type I and III IFNs upon Af stimulation.
Reduced FOXO1 expression in GC B cells from mice lacking regulatory CD4+ T cell–derived IL-10. Reduced FOXO1 expression in GC B cells from mice lacking.
Comparison of repertoire distributions to baseline.
Enhanced expression of TLR7 protein in PBMCs from women.
Tfr cells robustly secrete IL-10 after acute viral infection.
Tfr cell–derived IL-10 is important for B cell differentiation and the GC response. Tfr cell–derived IL-10 is important for B cell differentiation and.
DC subset cooperation for activation of antiviral T cells.
Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.
Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived.
Macrophage-resident NRP1 mitigates cytokine release and proinflammatory polarization. Macrophage-resident NRP1 mitigates cytokine release and proinflammatory.
T-bethi MP cells produce IFN-γ in response to IL-12.
Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.
Analysis of plasmablast responses in one naïve and three DENV-experienced donors. Analysis of plasmablast responses in one naïve and three DENV-experienced.
Protein sequence alignment of the NS3 helicase–encoding region of 63 flaviviruses demonstrates conservation of a KIR2DS2-binding peptide. Protein sequence.
Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy. Peanut-specific TH2A cells are specifically targeted during immunotherapy.
Blood Tfr cells are indicators of ongoing humoral activity.
Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria. Inhibiting or altering.
FIP200 maintains microRNA1198-5p expression via Ago2 in naïve T cells.
Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.
Antigen-specific immune responses are enhanced in hypertension.
APCs from hypertensive mice present antigens more efficiently.
Evaluation of multidonor class Ig sequences obtained from H5N1 and H7N9 vaccinated donors. Evaluation of multidonor class Ig sequences obtained from H5N1.
MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.
CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A)
Innate immune and fibrinolytic systems cooperate also during bacterial infections. Innate immune and fibrinolytic systems cooperate also during bacterial.
CD4+CLA+CD103+T cells from human blood and skin share a functional profile. CD4+CLA+CD103+T cells from human blood and skin share a functional profile.
Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.
MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded.
Detection of neoantigen-specific T cell recognition in cancer.
MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. PBMCs.
HFcγRIIA-expressing platelets are sufficient to induce anaphylaxis in resistant mice. hFcγRIIA-expressing platelets are sufficient to induce anaphylaxis.
Northern blot analysis of hY4 in CLL-derived exosomes and cells.
Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.
BMS blocks functional responses in primary immune cells driven by IFNα
Tfr cells respond better to immunization with self-antigens than with foreign antigens. Tfr cells respond better to immunization with self-antigens than.
MR1Ts respond to microbially derived ligands loaded on hpMR1 tetramers
AEGIS autonomous targeting process.
Human Tfr cells do not express CD25.
Human basophils are unresponsive to contact-dependent or contact-independent inhibition by Tregs. Human basophils are unresponsive to contact-dependent.
Blood Tfr cells are immature but are not committed in the thymus.
IL-33 is not critical for initiation of allergic airways disease phenotype. IL-33 is not critical for initiation of allergic airways disease phenotype.
IL-9–expressing TH cells are highly enriched in CCR4+/CCR8+ effector memory TH cells. IL-9–expressing THcells are highly enriched in CCR4+/CCR8+effector.
Memory phenotypes PBMC-derived MERS-CoV-specific T cells from CWs
REV-ERBα deficiency reduces frequency and number of NKp46+ ILC3s.
Circadian gene expression in ILC3s is associated with rhythmic cytokine expression. Circadian gene expression in ILC3s is associated with rhythmic cytokine.
Meningeal γδ T cells are biased toward IL-17 production.
Fetal-derived γδ T cells infiltrate the meninges from birth.
Cartoon model for the increased p-HLA display engendered by peptide splicing. Cartoon model for the increased p-HLA display engendered by peptide splicing.
In response to allergen, T cells and ILCs are equally important sources of IL-13. In response to allergen, T cells and ILCs are equally important sources.
Correlation of TAN phenotypes and TIL effector function.
Presentation transcript:

Human PBMC-derived MERS-CoV–specific T cells are multifunctional. Human PBMC-derived MERS-CoV–specific T cells are multifunctional. (A and C) PBMCs were stimulated with MERS-CoV structural protein–specific peptide pools. Frequency and percentage of cells expressing IFN-γ and TNF are shown. (B and D) PBMCs were stimulated with the N (B) or ME (D) peptide pools. CD4+ (B) or CD8+ (D) T cells were then analyzed for the indicated phenotypic markers. Jingxian Zhao et al. Sci. Immunol. 2017;2:eaan5393 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works