Role and potential therapeutic use of antibodies against herpetic infections  N. Clementi, F. Cappelletti, E. Criscuolo, M. Castelli, N. Mancini, R. Burioni, M. Clementi  Clinical Microbiology and Infection  Volume 23, Issue 6, Pages 381-386 (June 2017) DOI: 10.1016/j.cmi.2016.12.023 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Schematic representation of the most common herpesvirus antibody escape mechanisms. Antibodies, after recognizing virus proteins, are able to enhance the immune response using the Fc portion. As an example, Fcγ receptor on Fcγ receptor-expressing cells are able to bind antibody Fc portions stimulating the cellular immune response, through cytokine release (a). Herpesviruses are able to block antibody-mediated effector functions by binding the antibody Fc portion with their virus Fcγ receptor. Fcγ receptors present on infected cells can block antibodies already bound to viruses (b), those receptors on virus envelope can block the antibody already bound to infected cells (c) or, alternatively, the same receptors can even cause the so-called ‘antibody bridging’ between virus Fcγ receptor and target virus protein (d). In all these cases, herpesviruses greatly reduce the efficacy of antibody immune response in enhancing cellular immunity. Clinical Microbiology and Infection 2017 23, 381-386DOI: (10.1016/j.cmi.2016.12.023) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions