Understanding CARD Tricks in Apoptosomes

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Presentation transcript:

Understanding CARD Tricks in Apoptosomes Li Wang, Qi Qiao, Hao Wu Structure Volume 25, Issue 4, Pages 575-577 (April 2017) DOI: 10.1016/j.str.2017.03.013 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 CARD Disk in the Apaf-1 Apoptosome (A) Domain architectures of Apaf-1, caspase-9, and cytochrome c. (B) Top view of the cryo-EM structure of the Apaf-1 apoptosome (PDB ID: 3JBT). (C) Side view of the Apaf-1 holo-apoptosome showing the 4:4 Apaf-1:caspase-9 CARD disk above the heptameric wheel-like structure (PDB ID: 5JUY). (D) A schematic of structurally captured steps in CARD disk assembly and activation of Apaf-1 holo-apoptosome. (E) Superimposed type I, II, and III (for both Apaf-1:Apaf-1 and caspase-9:caspase-9) interactions between those in the crystal structure (PDB ID: 5WVC, Apaf-1 in slate and caspase-9 in orange) and the cryo-EM structure (PDB ID: 5JUY, Apaf-1 in cyan and caspase-9 in yellow). Structure 2017 25, 575-577DOI: (10.1016/j.str.2017.03.013) Copyright © 2017 Elsevier Ltd Terms and Conditions