Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure Natalie Greenwold, M.D.,

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Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure Natalie Greenwold, M.D., Eric Jauniaux, M.D., Ph.D., Beatrice Gulbis, M.D., Ph.D., Joanne Hempstock, Ph.D., Christine Gervy, Ph.D., Graham J Burton, M.D. Fertility and Sterility Volume 79, Issue 6, Pages 1373-1379 (June 2003) DOI: 10.1016/S0015-0282(03)00364-9

FIGURE 1 Immunohistochemical staining for β-hCG in 9-week villi with a normal karyotype. (a) Over most of the villous surface there is a strong reaction in the syncytiotrophoblast, and the underlying progenitor cytotrophoblast cells (arrows) are negative. (b) In some areas, the syncytiotrophoblast stains weakly, but the cytotrophoblast cells (arrows) react positively, indicating their activation and differentiation. Scale bars = 50 μm. Greenwold. Impact of karyotype in missed miscarriage.Fertil Steril 2003. Fertility and Sterility 2003 79, 1373-1379DOI: (10.1016/S0015-0282(03)00364-9)