Meghana R. K. Helder, MD, Nicholas T

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Presentation transcript:

Late durability of decellularized allografts for aortic valve replacement: A word of caution Meghana R.K. Helder, MD, Nicholas T. Kouchoukos, MD, Kenton Zehr, MD, Joseph A. Dearani, MD, Joseph J. Maleszewski, MD, Charles Leduc, MD, Courtney N. Heins, BS, Hartzell V. Schaff, MD The Journal of Thoracic and Cardiovascular Surgery Volume 152, Issue 4, Pages 1197-1199 (October 2016) DOI: 10.1016/j.jtcvs.2016.03.050 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Histopathologic findings of DAVAs in tissue sections stained with hematoxylin and eosin (left column) and corresponding Verhoeff-Van Gieson elastic (right column) stains, showing (A and B) full-thickness degeneration of the valve cusp and (C and D) marked calcification of the tubular component of the graft. (Original magnification, 40×.) The Journal of Thoracic and Cardiovascular Surgery 2016 152, 1197-1199DOI: (10.1016/j.jtcvs.2016.03.050) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Kaplan-Meier curves for freedom from reoperation. Patients implanted with a DAVA had a 92% (95% CI, 84%-100%) freedom from reoperation at 5 years postimplantation, compared with 100% in the control group. Freedom from reoperation at 10 years postoperatively was 51% (95% CI, 34%-76%) in patients receiving a DAVA, compared with 80% (95% CI, 60%-100%) in the control group (P = .06). The Journal of Thoracic and Cardiovascular Surgery 2016 152, 1197-1199DOI: (10.1016/j.jtcvs.2016.03.050) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Kaplan-meier curves for freedom from reoperation Kaplan-meier curves for freedom from reoperation. Curves vary significantly at 10 years (P = .06). The Journal of Thoracic and Cardiovascular Surgery 2016 152, 1197-1199DOI: (10.1016/j.jtcvs.2016.03.050) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions