Brian H. Shirts, Randall W. Burt, Sean J. Mulvihill, Lisa A

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Presentation transcript:

A Population-Based Description of Familial Clustering of Pancreatic Cancer  Brian H. Shirts, Randall W. Burt, Sean J. Mulvihill, Lisa A. Cannon–Albright  Clinical Gastroenterology and Hepatology  Volume 8, Issue 9, Pages 812-816 (September 2010) DOI: 10.1016/j.cgh.2010.05.012 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Distribution of the contribution to the GIF statistic by genetic distance for all pancreatic cancer cases versus 1000 sets of matched controls. Genetic distance 1 = parent/offspring, 2 = siblings, 3 = avunculars, 4 = first cousins, and so forth. Clinical Gastroenterology and Hepatology 2010 8, 812-816DOI: (10.1016/j.cgh.2010.05.012) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 An example of Utah high-risk pancreatic adenocarcinoma pedigree. The founding male (who has 2 spouses, both shown) had a total of 4306 descendants; 6 pancreatic cancers were observed; 2.22 were expected (P = .026). Clinical Gastroenterology and Hepatology 2010 8, 812-816DOI: (10.1016/j.cgh.2010.05.012) Copyright © 2010 AGA Institute Terms and Conditions