Fig. 2 In vitro and preclinical study with 18F-MPG.

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Fig. 2. Effects of Ang II on the p130Cas protein assayed by Western blotting. (A) The bands for p130Cas protein at 130 kDa are reduced by 10-7 M Ang II.

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Fig. 1. TP is highly expressed in myeloma.

Examples of functional imaging biomarkers in two DCA responders

The biodistribution and pharmacokinetics of [68Ga]Ga-1 in the orthotopic xenograft mice using µPET dynamic acquisitions. The biodistribution and pharmacokinetics.

EPR-based tumor uptake of [68Ga]Ga-1 for effective PET imaging.

Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.

Fig. 1. Potent and selective down-regulation of KRAS mRNA and protein by AZD4785 in vitro and in vivo. Potent and selective down-regulation of KRAS mRNA.

Fig. 5. Circulating PPi concentration does not correlate with severity of calcification phenotype in mice. Circulating PPi concentration does not correlate.

Fig. 4. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin expression. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin.

Fig. 1. [11C]Martinostat images of all subjects show high cortical binding and distinct gray-white matter differences. [11C]Martinostat images of all subjects.

Fig. 2. Pharmacologic inhibition of ALK impairs STING activation.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 8. Gene and protein changes in ALK-dependent STING pathways in human sepsis. Gene and protein changes in ALK-dependent STING pathways in human sepsis.

β-ARs signal cooperatively with mutant EGFR and inactivate LKB1

Analysis of brain and spinal cord of treated Gaa−/− mice and controls

Fig. 3. A circadian rhythm in fibroblast wound-healing response.

S534 phosphorylation affects DNA binding and gene expression by NF-κB at late time points through regulation of p65 stability. S534 phosphorylation affects.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Fig. 1 DMF promotes viral infection.

Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.

Fig. 2. GPC3 expression in normal and tumor tissues.

Fig. 5. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic.

Fig. 5. Pharmacological JAK2 inhibition in vivo abrogates tumor-initiating potential after chemotherapy. Pharmacological JAK2 inhibition in vivo abrogates.

Fig. 5 A competent Fc is required for the antitumor immune response.

Fig. 3. Fc fusion GDF15 molecules improve metabolic parameters in obese mice and obese cynomolgus monkeys. Fc fusion GDF15 molecules improve metabolic.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Fig. 5. Toxin production and release in vitro.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Fig. 5 Combination intravenous reovirus and checkpoint inhibition in an orthotopic syngeneic brain tumor model. Combination intravenous reovirus and checkpoint.

Fig. 1. Muscles of LAMA2 MD patients and dyW/dyW mice contain high amounts of laminin-α4 and show deficits in BM. Muscles of LAMA2 MD patients and dyW/dyW.

Fig. 6. Apoptotic MSCs exert in vivo immunosuppression in a TH2-type inflammation model in the absence of cytotoxic cells. Apoptotic MSCs exert in vivo.

Fig. 3 In situ vaccination with CpG and anti-OX40 is therapeutic in a spontaneous tumor model. In situ vaccination with CpG and anti-OX40 is therapeutic.

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Fig. 4 DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft tumor models. DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft.

Fig. 1. Neurobehavioral testing in YG8R mice transplanted with wild-type mouse HSPCs. Neurobehavioral testing in YG8R mice transplanted with wild-type.

Fig. 2 Whisker deprivation accelerates and enhances behavioral recovery after right S1FP photothrombosis. Whisker deprivation accelerates and enhances.

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Fig. 5 Local gel scaffold for T cell memory response.

Fig. 4 Whisker deprivation–induced remapping is stable beyond the deprivation period. Whisker deprivation–induced remapping is stable beyond the deprivation.

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Fig. 1 BX795 suppresses HSV-1 infection.

Fig. 7 Improvement of clinical score and axon pathology by nasal IL-4 treatment during chronic EAE. Improvement of clinical score and axon pathology by.

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Volume 23, Issue 4, Pages (April 2015)

Volume 23, Issue 4, Pages (April 2015)

Fig. 4 PD-L1 expression is found in the spleen and the BM of mice transplanted with JAK2V617F-transduced bone marrow. PD-L1 expression is found in the.

Fig. 7. mRIPO therapy restricts tumor growth and produces antigen-specific antitumor immunity. mRIPO therapy restricts tumor growth and produces antigen-specific.

Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.

Fig. 3. TKI sensitivity assessed by the MANO method.

Fig. 4 Analysis of ISO response in vitro in neonatal cardiomyocytes.

Fig. 4. Dabrafenib and trametinib changed the cellular components of the tumor microenvironment. Dabrafenib and trametinib changed the cellular components.

Fig F-FGln shows uptake in human gliomas undergoing progression.

Fig. 3 CSF1 is expressed in human melanoma.

Fig. 2. Cellular response to FolamiRs in vitro.

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Fig. 6 DMF inhibits NF-κB translocation upon infection.

Fig. 1 LB100 and LB102 specifically inhibit PP2A phosphatase activity and the growth of BCR-ABL+ cells. LB100 and LB102 specifically inhibit PP2A phosphatase.

CSF1 secretion by melanoma cells is induced by CTL-derived cytokines

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Leptin and amylin signaling.

Genetic EGFR ablation in K-RAS–mutated lung AC reduces tumor growth

Impaired in vitro adipogenic differentiation parallels elevated HDAC9 expression. Impaired in vitro adipogenic differentiation parallels elevated HDAC9.

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Western blotting for GluR1.

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Fig. 2 In vitro and preclinical study with 18F-MPG.

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Fig. 2 In vitro and preclinical study with 18F-MPG. In vitro and preclinical study with 18F-MPG. (A) Quantitative uptake of 18F-MPG in four NSCLC cell lines and pretreatment with gefitinib. Data are means ± SD of three independent experiments. **P < 0.01 versus line-matched 18F-MPG uptake in HCC827 cells, Student’s t test. (B) The autoradiography and the same Western blot membrane stained with E746-A750–specific antibody. A single 18F-labeled protein band corresponds to the predominant band of ~175 kDa. Graphs next to the blots show densitometric quantification of autoradiogram band normalized to background. ***P < 0.001 versus HCC827. GAPDH, glyceraldehyde-3-phosphate dehydrogenase. (C) Decay-corrected whole-body coronal PET images of HCC827, H1975, H520, and H358 tumor-bearing mice at 30, 60, and 120 min after injection of 3.7 megabecquerels (MBq; 100 μCi) of 18F-MPG (red arrows indicate the location of the tumors). % ID/g, percentage of injected dose per gram. (D) Comparison of tumor/muscle ratios of 18F-MPG and 18F-FDG at 60 min after injection of 3.7 MBq (100 μCi) of tracer in different tumor-bearing mice (n = 6 per group) as measured by PET imaging. Data are means ± SD. ***P < 0.001 versus line-matched 18F-MPG uptake in HCC827 cells, analysis of variance (ANOVA) with the Newman-Keuls multiple comparison test. 18F-FDG uptake versus 18F-MPG uptake in HCC827, ANOVA with the Newman-Keuls multiple comparison test. Xilin Sun et al., Sci Transl Med 2018;10:eaan8840 Published by AAAS