Wall Stress and Geometry of the Thoracic Aorta in Patients With Aortic Valve Disease Barry J. Doyle, PhD, Paul E. Norman, DS, Peter R. Hoskins, DSc, David.

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Wall Stress and Geometry of the Thoracic Aorta in Patients With Aortic Valve Disease Barry J. Doyle, PhD, Paul E. Norman, DS, Peter R. Hoskins, DSc, David E. Newby, DSc, Marc R. Dweck, MD, PhD The Annals of Thoracic Surgery Volume 105, Issue 4, Pages 1077-1085 (April 2018) DOI: 10.1016/j.athoracsur.2017.11.061 Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 This example of a control aorta shows the (A) three-dimensional reconstruction, (B) geometric measurements, and (C) computational mesh of finite elements. The Annals of Thoracic Surgery 2018 105, 1077-1085DOI: (10.1016/j.athoracsur.2017.11.061) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 All correlations between variables for the entire cohort. (A–G) These graphs show geometry relationships, (H) shows wall stress with age, (I) shows blood pressure (BP), and (J) shows peak jet velocity. Correlation coefficients (r) and p values are shown for each relationship. The Annals of Thoracic Surgery 2018 105, 1077-1085DOI: (10.1016/j.athoracsur.2017.11.061) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Total centerline tortuosity and (B) descending aortic centerline tortuosity for each group. The horizontal line in the middle of each box indicates the median, the top and bottom borders of the box mark the 75th and 25th percentiles, respectively, and the whiskers mark the maximum and minimum values. The Annals of Thoracic Surgery 2018 105, 1077-1085DOI: (10.1016/j.athoracsur.2017.11.061) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 The 99th percentile of peak wall stress for each group under (A) patient-specific and (B) standardized 120 mm Hg blood pressure conditions. The horizontal line in the middle of each box indicates the median, the top and bottom borders of the box mark the 75th and 25th percentiles, respectively, and the whiskers mark the maximum and minimum values. The Annals of Thoracic Surgery 2018 105, 1077-1085DOI: (10.1016/j.athoracsur.2017.11.061) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 The 99th percentile of peak von Mises wall stress contours at patient-specific blood pressure in patients from each group. (Top row) Cases with highest wall stress. (Middle row) Cases closest to the mean wall stress (see Table 1). (Bottom row) Cases with the lowest wall stress in the group. The color bar refers to all cases and all units are MPa. Cases are not to size scale. The Annals of Thoracic Surgery 2018 105, 1077-1085DOI: (10.1016/j.athoracsur.2017.11.061) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions