Focus of research group (I)

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Presentation transcript:

Focus of research group (I) Name PI: Jan Van den Bossche Department, UMC: Molecular Cell Biology and Immunology, VUmc Size of research group: Current mission, vision and aims : “Understanding and targeting macrophage immunometabolism” 4 PhD’s: Jeroen Baardman Sanne Verberk Kyra de Goede (CCA) Karl Harber Glycolysis PPP Fast ATP Biosynthesis OXPHOS Sustained ATP Long-lived

Focus of research group (II) Current expertise : Macrophage (& monocyte) biology: Metabolic characterization Functional profiling In-dept phenotyping Reprogramming Seahorse metabolic flux analysis, high-end cytometry, primary macrophage cultures Current funding : Hartstichting senior postdoc grant (2018-2022) CCA PhD grant (2018-2022) ACS PhD grant (2019-2022) Hartstichting junior postdoc grant & VENI (2013-2018) Acly fl/fl * LysM-Cre 2018

Collaborations in ACS : Pilot data: Future plans : ACS PhD project - Local immunometabolites shape inflammatory macrophages and atherosclerosis progression Focus on succinate: Collaborations in ACS : Liffert Vogt (Nephrology) : Effect of high salt on monocytes/macrophages Lab of Genetic Metabolic Diseases / Gepke Visser : Effect of FAO deficiencies on monocytes/macrophages Pilot data: Project outline: Necessary “infrastructure”: Patient samples : (fresh) plaques, blood samples