Can pharmacokinetic–pharmacodynamic parameters provide dosing regimens that are less vulnerable to resistance? P. Courvalin Clinical Microbiology and.

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Presentation transcript:

Can pharmacokinetic–pharmacodynamic parameters provide dosing regimens that are less vulnerable to resistance? P. Courvalin Clinical Microbiology and Infection Volume 14, Issue 11, Pages 989-994 (November 2008) DOI: 10.1111/j.1469-0691.2008.02081.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Pharmacokinetic curves after one or two administration(s) of an antibiotic. MIC, minimal inhibitory concentration; MPC, mutation prevention concentration; MSW, mutation selection window; IRD, induction revolving door. Clinical Microbiology and Infection 2008 14, 989-994DOI: (10.1111/j.1469-0691.2008.02081.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Growth of VanA-type methicillin-resistant Staphylococcus aureus in the absence (Vm0) or in the presence of 6 mg/L vancomycin (Vm6) after overnight culture with or without vancomycin (6 mg/L). The lines indicate the ratio of the vancomycin concentration in the overnight culture/vancomycin concentration in the culture medium. IRD, induction revolving door. Clinical Microbiology and Infection 2008 14, 989-994DOI: (10.1111/j.1469-0691.2008.02081.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions