Fig. 3 FMAEs promote infection by VSVΔ51.

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Fig. 3 FMAEs promote infection by VSVΔ51. FMAEs promote infection by VSVΔ51. (A) Structures of FAEs (DEF) and maleic acid esters (DEM and DMM). (B) Metabolism of DMF. DMF is hydrolyzed into monomethyl fumarate (MMF), which in turn is metabolized into FA. FA subsequently enters the Krebs cycle. (C) 786-0 cells or (D) CT26WT ex vivo tumor cores were pretreated with various FMAEs and analogs for 4 hours and subsequently infected with oncolytic VSVΔ51 expressing GFP at (C) an MOI of 0.01 or (D) 1 × 104 PFU. Twenty-four hours after infection, we obtained fluorescence images of the infected 786-0 cells or CT26WT tumor cores. Corresponding viral titers were determined from supernatants 48 hours after infection (n = 3; mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA, as compared to the untreated counterpart). Mohammed Selman et al., Sci Transl Med 2018;10:eaao1613 Published by AAAS