E. W. Bradley, L. R. Carpio, D. F. Amanatullah, S. Kakar, L. E. Ta, M

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Presentation transcript:

Phlpp1 deletion increases Fgf18 expression and protects against surgically-induced osteoarthritis E.W. Bradley, L.R. Carpio, D.F. Amanatullah, S. Kakar, L.E. Ta, M.E. McGee-Lawrence, A.C. Newton, J.J. Westendorf Osteoarthritis and Cartilage Volume 23, Pages A38-A39 (April 2015) DOI: 10.1016/j.joca.2015.02.090 Copyright © 2015 Terms and Conditions

Figure 1(A) PHLPP1 IHC in human articular cartilage from patients undergoing total joint arthroplasty for OA or FNFx. (B) OARSI scores from DMM surgeries performed on WT or Phlpp1-/- mice. (C) Fgf18 expression was determined in Phlpp1-/- cells by qPCR. (D-E) Fgf18 expression and Alcain blue staining of WT micromasses treated with the Phlpp1 inhibitor NCS117079. *p<0.05. Osteoarthritis and Cartilage 2015 23, A38-A39DOI: (10.1016/j.joca.2015.02.090) Copyright © 2015 Terms and Conditions