Changes in Cerebral Vascular Reactivity Occur Early During Cardiopulmonary Bypass in the Rat Thomas Modine, MD, Richard Azzaoui, MD, Thavarak Ouk, PhD,

Slides:

Advertisements

Similar presentations

Assessment of Cerebral Blood Flow With Transcranial Doppler in Right Brachial Artery Perfusion Patients Ümit Karadeniz, MD, Özcan Erdemli, MD, Mehmet.

Advertisements

Antithrombin Administration in Patients With Low Antithrombin Values After Cardiac Surgery: A Randomized Controlled Trial Domenico Paparella, MD, Crescenzia.

Intraaortic Counterpulsation During Cardiopulmonary Bypass Impairs Distal Organ Perfusion Steinar Lundemoen, MD, Venny Lise Kvalheim, MD, PhD, Øyvind.

Direct Spinal Cord Perfusion Pressure Monitoring in Extensive Distal Aortic Aneurysm Repair Christian D. Etz, MD, PhD, Gabriele Di Luozzo, MD, Stefano.

Diabetes Upregulation of Cyclooxygenase 2 Contributes to Altered Coronary Reactivity After Cardiac Surgery Jun Feng, MD, PhD, Kelsey Anderson, Arun K.

Comparative study of retrograde and selective cerebral perfusion with transcranial Doppler Yoshihisa Tanoue, MD, Ryuji Tominaga, MD, Yoshie Ochiai, MD,

Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress Munir Boodhwani,

Cerebral Oxygen Saturation Does Not Normalize Until After Stage 2 Single Ventricle Palliation Kathleen N. Fenton, MD, Katherine Lessman, BS, Kimberly.

Vasorelaxation Induced by New Third-Generation Dihydropyridine Calcium Antagonist Azelnidipine in Human Internal Mammary Artery Ge Gao, MD, PhD, Xiao-Cheng.

Does Roller Pump–Induced Pulsatile CPB Perfusion Affect Microvascular Fluid Shifts and Tissue Perfusion? Bjørg Elvevoll, MD, Steinar Lundemoen, MD, PhD,

A Closed Perfusion System With Heparin Coating and Centrifugal Pump Improves Cardiopulmonary Bypass Biocompatibility in Elderly Patients Lena Lindholm,

Amit Mathur, MD, Maher Baz, MD, E

Chronic Atrial Fibrillation Is Associated With Reduced Survival After Aortic and Double Valve Replacement Richard Schulenberg, MD, Polychronis Antonitsis,

Total Liquid Ventilation Reduces Lung Injury in Piglets After Cardiopulmonary Bypass Lijun Jiang, MD, Qiang Wang, MD, Yinglong Liu, MD, Ming Du, MD, Xiangdong.

Endothelial Progenitor Cells are Mobilized After Cardiac Surgery

Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery Massimo Chello, MD, Amedeo Anselmi, MD, Cristiano.

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

Outbreak of Middle East Respiratory Syndrome-Coronavirus Causes High Fatality After Cardiac Operations Rakan I. Nazer, MD The Annals of Thoracic Surgery

Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Basel Ramlawi, MD, MMSc, Hasan Otu, PhD, Shigetoshi Mieno, MD, Munir.

John Alfred Carr, MD, Joseph J. Amato, MD, Robert S.D. Higgins, MD

Uncoupling of Myocardial β-Adrenergic Receptor Signaling During Coronary Artery Bypass Grafting: The Role of GRK2 Christian F. Bulcao, MD, Prakash K.

James D. St. Louis, MD The Annals of Thoracic Surgery

Maternal-Fetal Interactions in Fetal Cardiac Surgery

Mariano E. Brizzio, MD, Alex Zapolanski, MD, Richard E

Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery John L Francis, PhD, George J Palmer, MD, Rebecca Moroose,

Who Do You Say You Are? The Annals of Thoracic Surgery

Cardiac Output Augmentation During Hypoxemia Improves Cerebral Metabolism After Hypothermic Cardiopulmonary Bypass Jess M. Schultz, MD, Tara Karamlou,

Congenital Absence of Bilateral Common Carotid Arteries

Relationship Between Antiinflammatory Cytokine Interleukin-10 and Lactate Concentrations in Neonates Undergoing the Arterial Switch Operation Kyrylo.

Quantification of Lipid Filtration and the Effects on Cerebral Injury During Cardiopulmonary Bypass Richard W. Issitt, FCCP, Ian Harvey, LCCP, Bronagh.

John S. Ikonomidis, MD, PhD, Ebony J

Use of Amiodarone After Major Lung Resection

Antithrombin Administration in Patients With Low Antithrombin Values After Cardiac Surgery: A Randomized Controlled Trial Domenico Paparella, MD, Crescenzia.

Aprotinin Exerts Differential and Dose-Dependent Effects on Myocardial Contractility, Oxidative Stress, and Cytokine Release After Ischemia-Reperfusion

Coronary surgery without cardiotomy suction and autotransfusion reduces the postoperative systemic inflammatory response Martin Westerberg, MD, Anders.

Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury Daijiro Hori, MD, Masahiro Ono, MD, PhD, Thomas.

Masahiro Ono, MD, PhD, Charles Brown, MD, Jennifer K

Increased cerebral and renal endothelial nitric oxide synthase gene expression after cardiopulmonary bypass in the rat C. David Mazer, MD, Francoise.

Embolized Methyl Methacrylate to the Right Atrium After Kyphoplasty

Cassandra Joffs, MD, Himali R. Gunasinghe, BS, Marlina M

Impact of Residency Status on Perfusion Times and Outcomes for Coronary Artery Bypass Graft Surgery Constance K. Haan, MD, Sarah Milford-Beland, MS,

Editorial Board, January 2010

Bradford B. Smith, MD, Matthew A

Red Blood Cell Transfusion Is Associated With Troponin Release After Elective Off- Pump Coronary Artery Bypass Surgery Fausto Biancari, MD, PhD, Eeva-Maija.

Statin in Combination With β-Blocker Therapy Reduces Postoperative Stroke After Coronary Artery Bypass Graft Surgery Denis Bouchard, MD, Michel Carrier,

Hypothermic Low-Flow Cardiopulmonary Bypass Impairs Pulmonary and Right Ventricular Function More Than Circulatory Arrest Jess M. Schultz, MD, Tara Karamlou,

High Flow Rates During Modified Ultrafiltration Decrease Cerebral Blood Flow Velocity and Venous Oxygen Saturation in Infants Rosendo A. Rodriguez, MD,

Completely Thrombosed Tricuspid Pouch Mimicking a Cardiac Tumor

Aaron J. Lindsay, MD, Meng Xu, MS, Daniel I. Sessler, MD, Eugene H

Vacuum-Assisted Closure for the Treatment of Complex Chest Wounds

Georg Matheis, MD, Friedhelm Beyersdorf, MD

Neurocognitive Function and Cerebral Emboli: Randomized Study of On-Pump Versus Off-Pump Coronary Artery Bypass Surgery Reza Motallebzadeh, MRCS, J.

Role of Nitric Oxide Pathway in Placental Dysfunction Following Fetal Bypass Christopher Lam, BS, R. Scott Baker, BS, Jerri McNamara, CCP, Robert Ferguson,

Pulsatile Pulmonary Perfusion During Cardiopulmonary Bypass Reduces the Pulmonary Inflammatory Response Matthias Siepe, MD, Ulrich Goebel, MD, Anne Mecklenburg,

Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide James D. McCully, PhD, Anthony J.

Preoperative Intraaortic Balloon Pump Enhances Cardiac Performance and Improves the Outcome of Redo CABG Jan T. Christenson, MD, PhD, Pierre Badel, MD,

Controlled Earlier Reperfusion for Brain Ischemia Caused by Acute Type A Aortic Dissection Hiroshi Munakata, MD, Kenji Okada, MD, PhD, Hiroya Kano, MT,

Invited Commentary The Annals of Thoracic Surgery

Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery.

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Transcutaneous Aortic Valve Implantation Using the Left Carotid Access: Feasibility and Early Clinical Outcomes Thomas Modine, MD, PhD, Arnaud Sudre,

Y. Joseph Woo, MD, Michael A. Acker, MD The Annals of Thoracic Surgery

Dumbor L. Ngaage, MD, FRCS (C-Th), Michael E. Cowen, FRCS

An Assay to Monitor Bivalirudin Levels on Cardiopulmonary Bypass

Reduced Cytokines Release and Myocardial Damage in Coronary Artery Bypass Patients Due to L-Arginine Cardioplegia Supplementation Luisa Colagrande, MD,

Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury Christine S Rinder, MD, Manuel Fontes, MD,

Influence of On-Pump Versus Off-Pump Techniques and Completeness of Revascularization on Long-Term Survival After Coronary Artery Bypass Omar M. Lattouf,

Karl A. Bocchieri, BS, CCP, S. Jacob Scheinerman, MD, L

Safety of low hematocrits during cardiopulmonary bypass

Harvey Edward Garrett, MD, Bradley A. Wolf, MD

Presentation transcript:

Changes in Cerebral Vascular Reactivity Occur Early During Cardiopulmonary Bypass in the Rat Thomas Modine, MD, Richard Azzaoui, MD, Thavarak Ouk, PhD, Georges Fayad, MD, Dominique Lacroix, MD, PhD, Henri Warembourg, MD, Regis Bordet, MD, PhD, Terence Gourlay, PhD The Annals of Thoracic Surgery Volume 82, Issue 2, Pages 672-678 (August 2006) DOI: 10.1016/j.athoracsur.2006.03.061 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Arterial pressure in the cardiopulmonary bypass (CPB) and sham groups of animals. The mean femoral arterial pressures were not significantly different between the groups. The data are expressed as mean ± SD. (Triangles = carotid CPB; diamonds = carotid sham; squares = femoral CPB; circles = femoral sham.) The Annals of Thoracic Surgery 2006 82, 672-678DOI: (10.1016/j.athoracsur.2006.03.061) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Blood gas data in the cardiopulmonary bypass (CPB) and sham arms of the study. Both PaO2and PaCO2 are shown, and there were no statistically significant differences between the groups in terms of either factor. (Diamonds = carotid PaO2; triangles = caudal PaO2; squares = carotid PaCO2; X = caudal PaCO2; post-op = postoperative; pre-op = preoperative; T = time.) The Annals of Thoracic Surgery 2006 82, 672-678DOI: (10.1016/j.athoracsur.2006.03.061) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 The myogenic tonus response in middle cerebral arteries, the contractile response to incrementally increasing transmural pressure (TMP), did not illicit any statistically significant differences between the groups. The data are expressed as mean ± SD and represent the percent (%) change in the precontracted tonus. (Squares = cardiopulmonary bypass [CPB] 30 minutes; diamonds = sham CPB 30 minutes; triangles = CPB 60 minutes; circles = sham CPB 60 minutes.) The Annals of Thoracic Surgery 2006 82, 672-678DOI: (10.1016/j.athoracsur.2006.03.061) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 The response of precontracted middle cerebral artery to acetylcholine (ACHOL [endothelium-dependent vasoreactivity]). The results are shown as mean ± SD and represent the percent (%) relaxation of serotonin-induced preconstriction. The degree of relaxation was substantially diminished in the cardiopulmonary bypass (CPB) group, confirming an alteration in dependent vasoreactivity. (conc = concentration; gray boxes = CPB 30 minutes; black triangles = CPB 60 minutes; gray triangles = sham 30 minutes; black boxes = sham 60 minutes.) The Annals of Thoracic Surgery 2006 82, 672-678DOI: (10.1016/j.athoracsur.2006.03.061) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Plasma tumor necrosis factor-α (TNFα) plasma concentration in the cardiopulmonary bypass (CPB) and sham groups. The CPB groups were associated with higher terminal levels. There was no significant difference between the CPB groups at termination, suggesting that the response occurs early in the CPB period. (Diagonal stripe bar = CPB 30 minutes; vertical stripe bar = CPB 60 minutes; open bar = sham 30 minutes; gray bar = sham 60 minutes.) The Annals of Thoracic Surgery 2006 82, 672-678DOI: (10.1016/j.athoracsur.2006.03.061) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Immunohistochemical analysis of brain sections. (a) Sections from the sham rats display the vascular wall with low intensity staining. (b) In contrast, cardiopulmonary bypass was associated with a significant enhancement of vascular wall staining in the 30-minute cardiopulmonary bypass (T30 CPB) group. (c) The negative control (sacrificed animals) shows no staining for intercellular adhesion molecule-1. The Annals of Thoracic Surgery 2006 82, 672-678DOI: (10.1016/j.athoracsur.2006.03.061) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions