Pycno2016-03 Pycnogenol® benign prostatic hyperplasia 75 patients with BPH 22 Pycnogenol® 150 mg/day 27 Controls 26 dutasteride (0.5 mg/day) and finasteride of (5 mg day) 8 weeks follow-up Effects of Pycnogenol® on BPH symptoms and ultrasound investigations

Pycno2016-03 Pycnogenol® benign prostatic hyperplasia Prostate a gland that is part of the male reproductive system  surrounds the upper portion of the urethra (the tube that carries urine out of the body).

Common signs and symptoms of BPH include: Frequent or urgent need to urinate. Increased frequency of urination at night (nocturia) Difficulty starting urination. Weak urine stream or a stream that stops and starts. Dribbling at the end of urination. Straining while urinating. Inability to completely empty the bladder.

Pycnogenol® improves urinary symptoms in BPH * * * * * * * *p<0.05 vs both controls 150 mg/day N=75 Ledda, A., et al. (2018). Minerva Med 109(4): 280-284.

Pycnogenol® improves bladder emptying in BPH * *p<0.05 vs both controls 150 mg/day N=75 Ledda, A., et al. (2018). Minerva Med 109(4): 280-284.

Pycnogenol® decreases oxidative stress in BPH * *p<0.05 vs both controls 150 mg/day N=75 Ledda, A., et al. (2018). Minerva Med 109(4): 280-284.

Pycnogenol® for benign prostatic hyperplasia improves urinary symptoms improves bladder emptying Decreases oxidative stress