Himanshu J. Patel, MDa, James J. Pilla, PhDa, David J

Slides:

Advertisements

Similar presentations

Manuel J. Antunes, MD, PhD, DSc

Advertisements

Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: Safety and efficacy studies

Left ventricular dysfunction after mitral valve repair—the fallacy of “normal” preoperative myocardial function Eduard Quintana, MD, Rakesh M. Suri,

Creating an ideal “off-test mode” for rotary left ventricular assist devices: Establishing a safe and appropriate weaning protocol after myocardial recovery

EMPA-REG OUTCOME: The Cardiologist's Point of View

Ventricular and pulmonary vascular remodeling induced by pulmonary overflow in a chronic model of pretricuspid shunt Daniele Linardi, MD, Alessio Rungatscher,

Early mitral valve surgery for chronic severe mitral regurgitation optimizes left ventricular performance and left ventricular mass regression Ken-ichi.

International Journal of Cardiology

Liam P. Ryan, MD, Kanji Matsuzaki, MD, PhD, Mio Noma, MD, Benjamin M

Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach Michael T. Kronon,

Potassium-channel opener cardioplegia is superior to St

The effect of biventricular pacing on cardiac function after weaning from cardiopulmonary bypass in patients with reduced left ventricular function: A.

Walter R. T. Witschey, PhD, Francisco Contijoch, MS, Jeremy R

Biodegradable vs Nonbiodegradable Cardiac Support Device for Treating Ischemic Cardiomyopathy in a Canine Heart Mutsunori Kitahara, MD, Shigeru Miyagawa,

Theoretic Impact of Infarct Compliance on Left Ventricular Function

Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage

Krasimira M. Mikhova, BSE, Creighton W

Heart reduction surgery: An analysis of the impact on cardiac function

Superiority of magnesium cardioplegia in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,

Functional comparison of anaesthetic agents during myocardial ischaemia–reperfusion using pressure–volume loops D.T. Andrews, A.G. Royse, C.F. Royse

Douglas L. Mann, MD, Michael A. Acker, MD, Mariell Jessup, MD, Hani N

Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure Mark F. Berry, MD, Timothy.

Levosimendan is superior to epinephrine in improving myocardial function after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats

Slice-by-Slice Pressure-Volume Loop Analysis Demonstrates Native Differences in Regional Cardiac Contractility and Response to Inotropic Agents Francisco.

Direct coronary artery perfusion from the left ventricle

Autosynchronized systolic unloading during left ventricular assist with a centrifugal pump Satoshi Kono, MDa, Kazunobu Nishimura, MD, PhDa, Takeshi Nishina,

Osamu Kawaguchi, MD, Walter E. Pae, MD, FACS, Bill B

Pulmonary artery banding for idiopathic dilative cardiomyopathy: A novel therapeutic strategy using an old surgical procedure Dietmar Schranz, MD, Alex.

Michael Argenziano, MDa, David A

Abul Kashem, MD, PhD, Sarmina Hassan, MD, PhD, Deborah L

Effect of acutely increased left ventricular afterload on work output from the right ventricle in conscious dogs Mohanraj K. Karunanithi, BE, MBiomedE,

Maximizing hemodynamic effectiveness of biventricular assistance by direct cardiac compression studied in ex vivo and in vivo canine models of acute heart.

Echocardiographic analysis of ventricular geometry and function during repair of congenital septal defects Joseph P Hart, MD, Santos E Cabreriza, BA,

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa,

Support Your Specialty

Differential effects of lumbar and thoracic epidural anaesthesia on the haemodynamic response to acute right ventricular pressure overload C Missant,

Mohanraj K. Karunanithi, BE, MBiomedE, Michael P

Modified Ultrafiltration Improves Left Ventricular Systolic Function In Infants After Cardiopulmonary Bypass Michael J. Davies, FRCSa, Khan Nguyen, MDa,

Mehrdad M. R. Amirhamzeh, MD, David A

Mitral valve repair in heart failure: Five-year follow-up from the mitral valve replacement stratum of the Acorn randomized trial Michael A. Acker, MD,

Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of.

Left ventricular volume and ejection fraction assessment with transoesophageal echocardiography: 2D vs 3D imaging B. Cowie, R. Kluger, M. Kalpokas British.

Rescue Bariatric Surgery for Obesity-induced Cardiomyopathy

Ventricular volume, chamber stiffness, and function after anteroapical aneurysm plication in the sheep Mark B. Ratcliffe, MDa, Arthur W. Wallace, MD,

Acute hemodynamic effects of restrictive mitral annuloplasty in patients with end-stage heart failure: Analysis by pressure-volume relations Sven A.F.

Dysfunction induced by ischemia versus edema: Does edema matter?

Mechanisms of Cardiomyoplasty: Comparative Effects of Adynamic Versus Dynamic Cardiomyoplasty Brian D. Mott, Joong Hwan Oh, Yoshio Misawa, Joe Helou,

REVERSAL OF IATROGENIC MYOCARDIAL EDEMA AND RELATED ABNORMALITIES OF DIASTOLIC PROPERTIES IN THE PIG LEFT VENTRICLE David A. Dean, MDa*, Mehrdad M. Amirhamzeh,

David C. Stuesse, MDa, George D. Giraud, MD, PhDb, Angelo A

Michael Kronon, MD. , Kirk S. Bolling, MD, Bradley S

Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine Helmut Habazettl, MD, Barbara W. Palmisano,

Ventricular restraint therapy for heart failure: The right ventricle is different from the left ventricle Lawrence S. Lee, MD, Ravi K. Ghanta, MD, Suyog.

Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction

Himanshu J. Patel, MDa, Edward B. Lankford, MD, PhDb, David J

The Journal of Thoracic and Cardiovascular Surgery

The role of a defined protocol for cardiac risk assessment in decreasing perioperative myocardial infarction in vascular surgery T.J. Bunt, MD Journal.

Evan Loh, MD, Edward B. Lankford, MD, PhD, David J

Human factors and cardiac surgery: A multicenter study

Polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia is equivalent to hypothermic potassium blood cardioplegia Joel S. Corvera,

Constantine L. Athanasuleas, MD, FACC

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Time-dependent response of both ventricles after septal ablation: Implications for biventricular support after left ventricular assist device placement

Michael T. Kronon, MD, Bradley S

L-arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts Michael T. Kronon, MD, Bradley.

Recovery of left ventricular function after surgical correction of mitral regurgitation caused by leaflet prolapse Rakesh M. Suri, MD, DPhil, Hartzell.

S. Fortier, MDa, R. G. Demaria, MD, PhDa,c, G. B. Pelletier, MDb, M

Similar neurobehavioral outcome after valve or coronary artery operations despite differing carotid embolic counts Michael J. Neville, MDa, John Butterworth,

Charanjit S. Rihal et al. JACC 2015;65:e7-e26

Right ventricular–pulmonary arterial coupling in patients after repair of tetralogy of Fallot Heiner Latus, MD, Wolfhard Binder, MD, Gunter Kerst, MD,

Presentation transcript:

Ten weeks of rapid ventricular pacing creates a long-term model of left ventricular dysfunction Himanshu J. Patel, MDa, James J. Pilla, PhDa, David J. Polidori, MDa, Sorin V. Pusca, MDa, Theodore A. Plappert, CVTb, Martin St John Sutton, FRCPb, Edward B. Lankford, MD, PhDb, Michael A. Acker, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 119, Issue 4, Pages 834-841 (April 2000) DOI: 10.1016/S0022-5223(00)70021-3 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 End-systolic elastance pressure-volume (PV) loops. Inflow occlusion PV loops obtained from one dog. The slope of the end-sysolic PV relationship decreases at peak HF compared with baseline. The decreased slope persists at 3 months of recovery. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 834-841DOI: (10.1016/S0022-5223(00)70021-3) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Echocardiographic time course of recovery after cessation of rapid ventricular pacing. Biweekly echocardiograms assessed recovery from pacing-induced failure in 7 dogs. By peak failure (HF), there is a significant decrease in ejection fraction (EF) and an increase in end-diastolic volume (EDV). By 2 weeks, EF partially improves (P < .05 vs HF and baseline [B] ), but there is no further improvement thereafter (P = not significant for 2 weeks vs 4 weeks, 4 weeks vs 6 weeks, 6 weeks vs 8 weeks, and 8 weeks vs 12 weeks). A similar pattern is seen for EDV, where partial recovery is apparent by 2 weeks, but EDV is stable thereafter. 2D, Two-dimensional; ANOVA, analysis of variance. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 834-841DOI: (10.1016/S0022-5223(00)70021-3) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Recovery of indices of contractility after cessation of pacing. In 9 dogs undergoing PV analysis, contractility indices of end-systolic elastance (Ees) and maximum dP/dt do not significantly improve after termination of pacing. Preload recruitable stroke work (PRSW), however, does, but at 8 and 12 weeks of recovery it is still significantly different from baseline values. There is no significant difference between 8 and 12 weeks of recovery in any of these indices of contractility. In a subset of these dogs (n = 4), PV analysis carried out at 22 weeks of recovery (dotted lines) showed no further improvement. Indices of LV systolic function at peak failure in this subset were within the range seen for the group as a whole. B, Baseline; HF, heart failure; ANCOVA, analysis of covariance; ANOVA, analysis of variance. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 834-841DOI: (10.1016/S0022-5223(00)70021-3) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Diastolic indices after prolonged tachycardia. In 9 dogs undergoing PV analysis, diastolic indices of minimum dP/dt and τ partially improve after termination of pacing but are still different from baseline (B). In a subset of dogs (n = 4) studied at 22 weeks of recovery (dotted lines) , no further improvement was seen. LV end-diastolic pressure (LVEDP), however, returns to baseline values at 8 weeks of recovery and remains normal in the subset of dogs studied at 22 weeks. Diastolic indices at peak failure in this subset were within the range seen for the whole group. ANOVA, Analysis of variance. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 834-841DOI: (10.1016/S0022-5223(00)70021-3) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 LV hypertrophy. The LV mass, measured by means of echocardiography, increased significantly at peak heart failure when compared with baseline values (B ; P = .0000007). The hypertrophy continued at 8 and 12 weeks of recovery. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 834-841DOI: (10.1016/S0022-5223(00)70021-3) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions