Yehuda G. Wolf, MD, Lars M. Rasmussen, MD, Yoav Sherman, MD, Warner P

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Nitroglycerin decreases medial smooth muscle cell proliferation after arterial balloon injury Yehuda G. Wolf, MD, Lars M. Rasmussen, MD, Yoav Sherman, MD, Warner P. Bundens, MD, Robert J. Hye, MD Journal of Vascular Surgery Volume 21, Issue 3, Pages 499-504 (March 1995) DOI: 10.1016/S0741-5214(95)70293-8 Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Cellular proliferation in the arterial wall 6 days after balloon injury (mean ± SE) in nitroglycerin-treated (n = 10, dark bars) and control (n = 10, light bars) group. Reduction (p < 0.005) in proliferation in entire arterial wall (left bars) was seen in nitroglycerin-treated group. This was mostly due to inhibition of proliferation (p < 0.005) in media (middle bars), whereas in neointima, difference in number of proliferating cells was not significant (right bars). Journal of Vascular Surgery 1995 21, 499-504DOI: (10.1016/S0741-5214(95)70293-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic sections of common carotid arteries 6 days after balloon injury. Arteries were harvested after administration of BrdU and were stained with a monoclonal anti-BrdU antibody. Proliferating cells that have incorporated BrdU appear dark. Internal elastic lamina is indicated with arrow.A, Active medial proliferation in control group. No cells are seen in intima. B, Active intimal proliferation in control group. Few BrdU-positive cells are seen in inner media underneath internal elastic lamina. C, Active intimal proliferation in nitroglycerin-treated group. On this section no BrdU-positive cells are seen in media. Journal of Vascular Surgery 1995 21, 499-504DOI: (10.1016/S0741-5214(95)70293-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic sections of common carotid arteries 6 days after balloon injury. Arteries were harvested after administration of BrdU and were stained with a monoclonal anti-BrdU antibody. Proliferating cells that have incorporated BrdU appear dark. Internal elastic lamina is indicated with arrow.A, Active medial proliferation in control group. No cells are seen in intima. B, Active intimal proliferation in control group. Few BrdU-positive cells are seen in inner media underneath internal elastic lamina. C, Active intimal proliferation in nitroglycerin-treated group. On this section no BrdU-positive cells are seen in media. Journal of Vascular Surgery 1995 21, 499-504DOI: (10.1016/S0741-5214(95)70293-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic sections of common carotid arteries 6 days after balloon injury. Arteries were harvested after administration of BrdU and were stained with a monoclonal anti-BrdU antibody. Proliferating cells that have incorporated BrdU appear dark. Internal elastic lamina is indicated with arrow.A, Active medial proliferation in control group. No cells are seen in intima. B, Active intimal proliferation in control group. Few BrdU-positive cells are seen in inner media underneath internal elastic lamina. C, Active intimal proliferation in nitroglycerin-treated group. On this section no BrdU-positive cells are seen in media. Journal of Vascular Surgery 1995 21, 499-504DOI: (10.1016/S0741-5214(95)70293-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Size of neointimal lesion (mean ± SE) 21 days after balloon injury in nitroglycerin-treated (n = 10, dark bars) and control (n = 10, light bars) group. Treatment was given for 7 days after balloon injury and was stopped 14 days before these measurements. There was no significant difference between groups when compared as absolute cross-sectional area (left) or as intimal/medial area ratios (right). Journal of Vascular Surgery 1995 21, 499-504DOI: (10.1016/S0741-5214(95)70293-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions