Laser-induced fluorescence detection of atherosclerotic plaque with hematoporphyrin derivative used as an exogenous probe Louis G. Prevosti, M.D., James.

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Presentation transcript:

Laser-induced fluorescence detection of atherosclerotic plaque with hematoporphyrin derivative used as an exogenous probe Louis G. Prevosti, M.D., James J. Wynne, Ph.D., Carl G. Becker, M.D., Ralph Linsker, M.D., Ph.D., G.Tom Shires, M.D. Journal of Vascular Surgery Volume 7, Issue 4, Pages 500-506 (April 1988) DOI: 10.1016/0741-5214(88)90338-2 Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Experimental block diagram to record surface fluorescence spectrum from rabbit aorta. Journal of Vascular Surgery 1988 7, 500-506DOI: (10.1016/0741-5214(88)90338-2) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Fluorescence spectrum taken from normal area of aorta of atherosclerotic rabbit given hematoporphyrin derivative. Signals I1 at 615 nm and I2 at 632 nm are used to calculate plaque index (see text). Journal of Vascular Surgery 1988 7, 500-506DOI: (10.1016/0741-5214(88)90338-2) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Fluorescence spectrum of normal aortic wall and atherosclerotic plaque from rabbit not given hematoporphyrin derivative. Spectra are identical in their wavelength dependence; plaque shows only difference in intensity. Journal of Vascular Surgery 1988 7, 500-506DOI: (10.1016/0741-5214(88)90338-2) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Fluorescence spectrum taken from plaque of atherosclerotic rabbit given hematoporphyrin derivative. There is a spectral peak at 632 nm, which corresponds to fluorescence peak of hematoporphyrin derivative. Journal of Vascular Surgery 1988 7, 500-506DOI: (10.1016/0741-5214(88)90338-2) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions