Significant Enhancement of Esophageal Pre-Epithelial Defense by Tegaserod: Implications for an Esophagoprotective Effect  Marek Majewski, Tomasz Jaworski, Irene Sarosiek, Sandra Sostarich, Katherine Roeser, Stanley A. Edlavitch, Jeffrey Kralstein, Grzegorz Wallner, Richard W. McCallum, Jerzy Sarosiek  Clinical Gastroenterology and Hepatology  Volume 5, Issue 4, Pages 430-438 (April 2007) DOI: 10.1016/j.cgh.2007.01.002 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Patient flow for the study. Clinical Gastroenterology and Hepatology 2007 5, 430-438DOI: (10.1016/j.cgh.2007.01.002) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Individual salivary bicarbonate outputs in response to therapy with tegaserod in basal conditions. *P < .001 vs placebo (Wilcoxon test). Clinical Gastroenterology and Hepatology 2007 5, 430-438DOI: (10.1016/j.cgh.2007.01.002) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 (A) Contribution of salivary and esophageal submucosal mucous glands to esophageal pre-epithelial defense before tegaserod. (B) Contribution of salivary and esophageal submucosal glands to esophageal pre-epithelial defense after tegaserod. Clinical Gastroenterology and Hepatology 2007 5, 430-438DOI: (10.1016/j.cgh.2007.01.002) Copyright © 2007 AGA Institute Terms and Conditions