The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition Geoffrey A. Vargish, Chris J. McBain Neuron

Slides:

Advertisements

Similar presentations

Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

NMDA Receptors in Dopaminergic Neurons Are Crucial for Habit Learning Lei Phillip Wang, Fei Li, Dong Wang, Kun Xie, Deheng Wang, Xiaoming Shen, Joe Z.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity Avishek.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others Jason P. Mitchell, C. Neil Macrae, Mahzarin R. Banaji Neuron.

The Current Role of Operative Venous Thrombectomy in Deep Vein Thrombosis Anthony J. Comerota Seminars in Vascular Surgery Volume 25, Issue 1, Pages 2-12.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Neuronal Synchronization along the Dorsal Visual Pathway Reflects the Focus of Spatial Attention Markus Siegel, Tobias H. Donner, Robert Oostenveld, Pascal.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Building Better Models of Visual Cortical Receptive Fields

Pentraxins Coordinate Excitatory Synapse Maturation and Circuit Integration of Parvalbumin Interneurons Kenneth A. Pelkey, Elizabeth Barksdale, Michael T.

Drosophila Olfaction: The End of Stereotypy?

Keeping ‘Trk’ of Antidepressant Actions

Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

PDF Has Found Its Receptor

Glycine at the Gate—from Model to Mechanism

Calcium Signaling and the Control of Dendritic Development

Enhanced Dendritic Integration by Ih Reduction in the Anterior Cingulate Cortex Increases Nociception Jasmine R. Dickinson, Grégory Scherrer Neuron

Pursuing the Link between Neurons and Behavior

Chinmo and Neuroblast Temporal Identity

Fibrinogen in the Nervous System: Glia Beware

The Autistic Neuron: Troubled Translation?

Street View of the Cognitive Map

α-Synuclein and Tau: Mitochondrial Kill Switches

There's More Than One Way to Scale a Synapse

Applying the Brakes: When to Stop Eating

Volume 68, Issue 2, Pages (October 2010)

Treating Obesity? It's in the Bag!

Learning about Synaptic GluA3

K+ Channel Regulation of Multicompartmental Signal Integration

Aligning a Synapse Neuron

Drosophila Olfaction: The End of Stereotypy?

Volume 68, Issue 5, Pages (December 2010)

Howard Eichenbaum, Neal J. Cohen Neuron

Zhenglin Gu, Jerrel L. Yakel Neuron

The Two Sides of Hippocampal Mossy Fiber Plasticity

Street View of the Cognitive Map

Endocannabinoids Mediate Neuron-Astrocyte Communication

Volume 91, Issue 6, Pages (September 2016)

Insect Odorant Receptors: Channeling Scent

Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease Michael S. Levine, Carlos Cepeda,

On the Integration of Space, Time, and Memory

Dilja D. Krueger, Nils Brose Neuron

SCOPing out Proteases in Long-Term Memory

The Back and Forth of Dendritic Plasticity

Linking Calcium to Aβ and Alzheimer's Disease

SCOPing out Proteases in Long-Term Memory

The Dopamine D2 Receptor: New Surprises from an Old Friend

Piezo channels Current Biology

Santosh Kesari, Charles D. Stiles Neuron

Contribution of Ih to LTP, Place Cells, and Grid Cells

David Hubel and Torsten Wiesel

Opening a “Wide” Window onto Taste Signal Transmission

In a Pickle: Is Cornichon Just Relish or Part of the Main Dish?

Presentation transcript:

The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition Geoffrey A. Vargish, Chris J. McBain Neuron Volume 89, Issue 5, Pages 889-891 (March 2016) DOI: 10.1016/j.neuron.2016.02.027 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Connecting Cannabinoid Function to Cognition (A) Schematic diagram of cannabinoid type 1 receptor expression (CB1R) and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel expression in hippocampal deep or superficial pyramidal cells (DPC and SPCs). (B) Diagram highlighting the intracellular pathway that connects CB1R activation to increased HCN-mediated Ih. (C) CB1R-mediated modulation of Ih influences temporal summation (left) as well as induction of Schaffer collateral LTP (middle) in SPCs. The CB1R- Ih pathway is also linked to impairments in spatial memory induced by CB1R agonists, such as cannabis, as highlighted by the object location memory test (right). Acute treatment with a CB1R agonist, WIN55,212-2, reduces object discrimination index in a CB1R- and HCN1-dependent manner. Neuron 2016 89, 889-891DOI: (10.1016/j.neuron.2016.02.027) Copyright © 2016 Elsevier Inc. Terms and Conditions