Left ventricular dysfunction after degenerative mitral valve repair: A question of better molecular targets or better surgical timing? Jordan D. Miller,

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Presentation transcript:

Left ventricular dysfunction after degenerative mitral valve repair: A question of better molecular targets or better surgical timing? Jordan D. Miller, PhD, Rakesh M. Suri, MD, DPhil The Journal of Thoracic and Cardiovascular Surgery Volume 152, Issue 4, Pages 1071-1074 (October 2016) DOI: 10.1016/j.jtcvs.2016.07.018 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Prevalence and potential mechanisms of postoperative left ventricular (LV) dysfunction. Note that roughly 20% of patients develop postoperative LV dysfunction, with the magnitude of that impairment being predictive of the likelihood of recovery of function. While numerous mechanisms have been proposed to underlie the transient impairment of LV function and its return to preoperative levels, few have been tested experimentally. Consequently, further research using experimental model systems to identify druggable molecular targets combined with multi-site, large-scale clinical studies to identify suitable biomarkers to trigger early intervention will be key to improving postoperative outcomes for all patients undergoing mitral valve repair surgery. MR, Mitral regurgitation; EF, ejection fraction; β-AR, β-adrenergic receptor. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 1071-1074DOI: (10.1016/j.jtcvs.2016.07.018) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Prevalence and potential mechanisms of postoperative left ventricular dysfunction. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 1071-1074DOI: (10.1016/j.jtcvs.2016.07.018) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions