Up-regulation of vascular endothelial growth factor mrna and angiogenesis after transmyocardial laser revascularization Keith A Horvath, MD, Elaine Chiu,

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Up-regulation of vascular endothelial growth factor mrna and angiogenesis after transmyocardial laser revascularization Keith A Horvath, MD, Elaine Chiu, BS, Dipen C Maun, BS, Jon W Lomasney, MD, Rodney Greene, BS, William H Pearce, MD, David A Fullerton, MD The Annals of Thoracic Surgery Volume 68, Issue 3, Pages 825-829 (September 1999) DOI: 10.1016/S0003-4975(99)00842-5

Fig 1 Northern blot analysis of vascular endothelial growth factor expression. Lanes 1 through 6 are from the ischemic zone of laser-treated animals. Lanes 10 through 15 are from the ischemic zone of untreated control animals. Lane 8 is from a human endothelial cell control. Lanes 7 and 9 are blank. The Annals of Thoracic Surgery 1999 68, 825-829DOI: (10.1016/S0003-4975(99)00842-5)

Fig 2 Vascular endothelial growth factor (VEGF) messenger RNA (mRNA) quantitation of northern blot data from transmyocardial laser revascularization (TMLR) and control animals. Left anterior descending artery (LAD) (nonischemic zone, solid bars) and Cx (ischemic zone, hatched bars) are compared for both groups of animals. The TMLR-treated ischemic zone shows increased VEGF mRNA compared with all other myocardium (∗p = 0.01). No difference in VEGF mRNA between the TMR LAD, control Cx or control LAD (†p = not significant). The Annals of Thoracic Surgery 1999 68, 825-829DOI: (10.1016/S0003-4975(99)00842-5)

Fig 3 Factor VIII immunohistochemical staining of myocardium. (A) Nonischemic zone from a laser-treated animal. (B) Ischemic zone from the same animal. There is a significant increase in the number of blood vessels in the laser-treated ischemic zone (original magnification, ×100). The Annals of Thoracic Surgery 1999 68, 825-829DOI: (10.1016/S0003-4975(99)00842-5)

Fig 4 Number of blood vessels per 200× high-powered microscopic field in the nonischemic zone (LAD, solid bars) and the ischemic zone (Cx, slashed bars) from laser-treated and control animals. The laser-treated ischemic zone had a significantly higher number of blood vessels per high-powered field compared with all other sections of myocardium (∗p = 0.01). There is no significant difference in the number of blood vessels per high-powered field between all other sections (†p = not significant). The Annals of Thoracic Surgery 1999 68, 825-829DOI: (10.1016/S0003-4975(99)00842-5)