Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy Jiashing Yu,

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Presentation transcript:

Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy Jiashing Yu, BS, Karen L. Christman, PhD, Eric Chin, BS, Richard E. Sievers, BS, Maythem Saeed, PhD, Randall J. Lee, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 137, Issue 1, Pages 180-187 (January 2009) DOI: 10.1016/j.jtcvs.2008.08.036 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Hematoxylin and eosin stain shows the presence of biopolymers in situ after 24 hours of injection. A, Infarcted myocardium treated with PBS. B, Infarcted myocardium treated with fibrin glue. C, Infarcted myocardium treated with alginate. The black arrow indicates the location of biopolymers. Scale bars = 1.0 mm. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 180-187DOI: (10.1016/j.jtcvs.2008.08.036) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Echocardiographic data. ∗Significant difference between groups (P < .05) at 5 weeks after injection (10 weeks after myocardial infarction [MI]). LV, Left ventricular; PBS, phosphate-buffered saline. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 180-187DOI: (10.1016/j.jtcvs.2008.08.036) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Histologic assessment 5 weeks after injection. Masson's trichrome staining showed the collagen deposition (blue) in the infarcted areas of the phosphate-buffered saline (PBS; A)–, fibrin (B)–, and alginate (C)–injected groups. Black arrows indicate the existence of alginate. The infarcted percentage of the left ventricle (LV; D) and wall thickness (E) were measured. Scale bars = 1.0 mm. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 180-187DOI: (10.1016/j.jtcvs.2008.08.036) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Increased arteriole density in the infarcted area. Smooth muscle actin staining showed visible arterioles of the phosphate-buffered saline (PBS) (A), fibrin (B), and alginate (C) groups. Quantitative analysis of arteriole density is presented in panel D. Scale bars = 100 μm. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 180-187DOI: (10.1016/j.jtcvs.2008.08.036) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Arterioles in the collagen deposition area. Smooth muscle actin staining of arterioles in the infarcted zone (A) and corresponding Trichrome staining (B). Scale bars = 100 μm. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 180-187DOI: (10.1016/j.jtcvs.2008.08.036) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions