Infant cardiopulmonary bypass: a procoagulant state

Slides:

Advertisements

Similar presentations

Impact of cardiac surgery using cardiopulmonary bypass on course of chronic lymphatic leukemia: a case-control study Evgenij V Potapov, MD, Heinz R Zurbrügg,

Advertisements

The effect of cardiotomy suction on the brain injury marker S100β after cardiopulmonary bypass Russell E Anderson, MD, PhD, Lars-Olof Hansson, MD, PhD,

David W. Barbara, MD, William J. Mauermann, MD, James R

Proinflammatory and antiinflammatory cytokines after cardiac operation: different cellular sources at different times Axel Franke, MD, Wolfgang Lante,

Timothy T. Cornell, MD, Lei Sun, PhD, Mark W. Hall, MD, James G

Investigating the Causes of Adverse Events

Growth and fibrinolytic parameters of human umbilical vein endothelial cells seeded onto cardiovascular grafts Jing Chuan Zhang, MDa,b, Johann Wojta,

James A Haugen, MBA, George E Miller, MD

Randomized Comparison Between Normothermic and Hypothermic Cardiopulmonary Bypass in Pediatric Open-Heart Surgery Massimo Caputo, MD, Simon Bays, Chris.

Cerebrospinal Fluid Markers of Brain Injury, Inflammation, and Blood-Brain Barrier Dysfunction in Cardiac Surgery Björn Reinsfelt, MD, PhD, Sven-Erik.

Jeffrey G. Gaca, MD, Shubin Sheng, PhD, Mani Daneshmand, MD, J

James L Zellner, MD, Scott B Kribbs, BS, B

Gene expression of inflammatory mediators in different chambers of the human heart Guro Valen, MD, PhD, Gabrielle Paulsson, PhD, Anna M Bennet, Göran.

The Society of Thoracic Surgeons Thoracic Surgery Practice and Access Task Force: 2014 Workforce Report John S. Ikonomidis, MD, PhD The Annals of Thoracic.

Bashir M Matata, PhD, Andrzej W Sosnowski, MD, Manuel Galiñanes

Coagulofibrinolysis during heparin-coated cardiopulmonary bypass with reduced heparinization Hiroshi Kumano, MD, PhD, Shigefumi Suehiro, MD, PhD, Koji.

Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery Massimo Chello, MD, Amedeo Anselmi, MD, Cristiano.

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

Patient Safety: Disclosure of Medical Errors and Risk Mitigation

An Analysis of Oxygen Consumption and Oxygen Delivery in Euthermic Infants After Cardiopulmonary Bypass With Modified Ultrafiltration Jia Li, MD, PhD,

Itaru Nagahiro, MD, Tyler White, PhD, Motoki Yano, MD, Carlos H. R

Human cytokine responses to coronary artery bypass grafting with and without cardiopulmonary bypass Martin Strüber, MD, Jochen T Cremer, MD, Bernhard.

James D. St. Louis, MD The Annals of Thoracic Surgery

Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery John L Francis, PhD, George J Palmer, MD, Rebecca Moroose,

Brain SPECT imaging and neuropsychological testing in coronary artery bypass patients R.Alan Hall, MD, David J Fordyce, PhD, Marie E Lee, MD, Brian Eisenberg,

Saving Lives Is More Important Than Abstract Moral Concerns: Financial Incentives Should Be Used to Increase Organ Donation Benjamin Hippen, MD, Lainie.

Clinical performance and biocompatibility of poly(2-methoxyethylacrylate)—coated extracorporeal circuits Serdar Gunaydin, MD, Bora Farsak, MD, Mustafa.

Modified Ross Procedure to Prevent Autograft Dilatation

Anne H Kuitunen, MD, Lasse J Heikkilä, MD, Markku T Salmenperä, MD

Lung Function and ECMO After Lung Transplantation

Editorial Board, January 2010

David L. Joyce, MD The Journal of Thoracic and Cardiovascular Surgery

Bradford B. Smith, MD, Matthew A

Platelet and Neutrophil Activation During Cardiac Surgical Procedures: Impact of Cardiopulmonary Bypass David S Morse, David Adams, Barbarajean Magnani

Hypothermic Low-Flow Cardiopulmonary Bypass Impairs Pulmonary and Right Ventricular Function More Than Circulatory Arrest Jess M. Schultz, MD, Tara Karamlou,

Roni M. Jacobsen, MD, Michael G. Earing, MD, Garick D

Drew-Anderson technique attenuates systemic inflammatory response syndrome and improves respiratory function after coronary artery bypass grafting Josef.

Interleukin-6 and “complex” cardiac myxoma

Inhibitory effect of milrinone on cytokine production after cardiopulmonary bypass Nobuhiko Hayashida, MD, PhD, Hiroshi Tomoeda, MD, Takeshi Oda, MD,

No benefit of reduced heparinization in thoracic aortic operation with heparin-coated bypass circuits Christian Olsson, MD, Agneta Siegbahn, MD, PhD,

Ronald A. Bronicki, MD, Carl L. Backer, MD, Harris P

Nitric Oxide Dose Response During Moderate and Severe Hypoxia in Swine

Markers for endothelial activation during open heart surgery

Time course of proinflammatory and anti-inflammatory responses after cardiac operation: monocyte HLA-DR expression Y.John Gu, MD, PhD, Willem van Oeveren,

Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass Jeffrey M.

Beware the malignant jellyfish

Anthony P.C Yim, MD, Song Wan, MD, PhD, Tak Wai Lee, Ahmed A Arifi

Sara K. Pasquali, MD, Matthew Hall, PhD, Jennifer S

Valvular heart operation is an independent risk factor for acute renal failure Antony D Grayson, Magdy Khater, FRCA, Mark Jackson, PhD, Mark A Fox, FRCA

Aprotinin Enhances the Endogenous Release of Interleukin-10 After Cardiac Operations Gary E Hill, Robert P Diego, Alfred H Stammers, Suzanne M Huffman,

Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery.

Neal S Goldstein, MD The Annals of Thoracic Surgery

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Comparison of Blood Activation in the Wound, Active Vent, and Cardiopulmonary Bypass Circuit Olivier Fabre, MD, PhD, André Vincentelli, MD, PhD, Delphine.

Endothelial Cell Injury in Cardiovascular Surgery

Induction of Interleukin-19 and Interleukin-22 After Cardiac Surgery With Cardiopulmonary Bypass Chung-Hsi Hsing, MD, Mei-Yi Hsieh, MS, Wei-Yu Chen,

Effects of Methylprednisolone and a Biocompatible Copolymer Circuit on Blood Activation During Cardiopulmonary Bypass Fraser D. Rubens, MD, Howard Nathan,

William T. Brinkman, MD, Morley A. Herbert, PhD, Syma L

Sunjay Kaushal, MD, PhD, Brody Wehman, MD

An alternative method of neck flexion after tracheal resection

Removal of an intrathoracic migrated fixation pin by thoracoscopy

An Assay to Monitor Bivalirudin Levels on Cardiopulmonary Bypass

Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury Christine S Rinder, MD, Manuel Fontes, MD,

High tissue affinity angiotensin-converting enzyme inhibitors improve endothelial function and reduce infarct size Harold L Lazar, MD, Yusheng Bao, MD,

Karl A. Bocchieri, BS, CCP, S. Jacob Scheinerman, MD, L

Safety of low hematocrits during cardiopulmonary bypass

Y.John Gu, MD, PhD, Piet W. Boonstra, MD, PhD, Willem van Oeveren, PhD

A randomized trial of antithrombin concentrate for treatment of heparin resistance Mathew R Williams, MD, Alyssa B D’Ambra, BA, James R Beck, Talia B.

Thrombophilic Variables Do Not Increase the Generation or Procoagulant Activity of Thrombin During Cardiopulmonary Bypass Peter Raivio, MD, Jari Petäjä,

Michelle C. Wallace, MD, James Jaggers, MD, Jennifer S

Presentation transcript:

Infant cardiopulmonary bypass: a procoagulant state James J Jaggers, MD, Meg C Neal, BSN, Peter K Smith, MD, Ross M Ungerleider, MD, Jeffrey H Lawson, MD, PhD The Annals of Thoracic Surgery Volume 68, Issue 2, Pages 513-520 (August 1999) DOI: 10.1016/S0003-4975(99)00644-X

Fig 1 Diagram of the procoagulant reactions occurring at the endothelial cell membrane level. See text for details. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)

Fig 2 Time course values of relative tissue plasminogen activator (t-PA) levels with a baseline level measured preoperatively in the operating room of 1.0. Values are displayed as the mean ± standard error of the mean. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)

Fig 3 Relative plasminogen activator inhibitor (PAI-1) levels with baseline level measured preoperatively of 1.0. Values are displayed as the mean ± standard error of the mean. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)

Fig 4 Induction of tissue factor activity on human umbilical vein endothelial cell culture when inoculated with the serum samples from the above time points. The preoperative sample is baseline and assigned a value of 1.0. Values are displayed as the mean ± standard error of the mean. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)

Fig 5 Induction of prothrombinase reaction activity on human umbilical vein endothelial cell culture when inoculated with the serum samples from the above time points. The preoperative sample is baseline and assigned a value of 1.0. Values are displayed as the mean ± standard error of the mean. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)

Fig 6 Plasma factor V levels displayed as percent of preoperative baseline value. Values represent the mean ± standard error of the mean. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)

Fig 7 Serum interleukin 1-β (IL-β) levels represented as the mean ± standard error of the mean. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)

Fig 8 Serum interleukin-6 (IL-6) levels represented as the mean ± standard error of the mean. The Annals of Thoracic Surgery 1999 68, 513-520DOI: (10.1016/S0003-4975(99)00644-X)