Intermediate survival in neonates with aortic atresia: A multi-institutional study Marshall L. Jacobs, MD, Eugene H. Blackstone, MD, Leonard L. Bailey,

Slides:

Advertisements

Similar presentations

Moderate Tricuspid Regurgitation With Left-Sided Degenerative Heart Valve Disease: To Repair or Not to Repair? Jose L. Navia, MD, Nicolas A. Brozzi,

Advertisements

Is return of angina after coronary artery bypass grafting immutable, can it be delayed, and is it important? P. Sergeant, MD, E. Blackstone, MD*, B.

Robert J. Dabal, MD, James K

Generating New Knowledge in Cardiac Interventions

Moderate Tricuspid Regurgitation With Left-Sided Degenerative Heart Valve Disease: To Repair or Not to Repair? Jose L. Navia, MD, Nicolas A. Brozzi,

Prognosis of patients removed from a transplant waiting list for medical improvement: Implications for organ allocation and transplantation for status.

Should lung transplantation be performed for patients on mechanical respiratory support? The US experience David P. Mason, MD, Lucy Thuita, MS, Edward.

Lars G. Svensson, MD, PhD, Lillian H. Batizy, MS, Eugene H

Determinants of repair type, reintervention, and mortality in 393 children with double- outlet right ventricle Timothy J. Bradley, MD, Tara Karamlou,

Effect of changes in postoperative spirometry on survival after lung transplantation David P. Mason, MD, Jeevanantham Rajeswaran, MSc, Liang Li, PhD,

Outcomes After Late Reoperation in Patients With Repaired Tetralogy of Fallot: The Impact of Arrhythmia and Arrhythmia Surgery Tara Karamlou, MD, Ilana.

Beyond the Aortic Root: Staged Open and Endovascular Repair of Arch and Descending Aorta in Patients With Connective Tissue Disorders Eric E. Roselli,

Endovascular versus open elephant trunk completion for extensive aortic disease Eric E. Roselli, MD, Sreekumar Subramanian, MD, Zhiyuan Sun, BS, Jahanzaib.

Surgical treatment of pseudoaneurysm of the thoracic aorta

Surgical Treatment of Postinfarction Left Ventricular Pseudoaneurysm

Factors influencing early and late outcome of the arterial switch operation for transposition of the great arteries Gil Wernovsky, MD* (by invitation),

The Optimal Timing of Stage-2-Palliation After the Norwood Operation

Reoperation After Mitral Valve Repair for Degenerative Disease

Is return of angina after coronary artery bypass grafting immutable, can it be delayed, and is it important? P. Sergeant, MD, E. Blackstone, MD*, B.

Lesion-specific outcomes in neonates undergoing congenital heart surgery are related predominantly to patient and management factors rather than institution.

Surgical management of competing pulmonary blood flow affects survival before Fontan/Kreutzer completion in patients with tricuspid atresia type I Travis.

Results of palliation with an initial pulmonary artery band in patients with single ventricle associated with unrestricted pulmonary blood flow Bahaaldin.

Prosthesis size and long-term survival after aortic valve replacement

Bilateral pulmonary arterial banding results in an increased need for subsequent pulmonary artery interventions Ryan R. Davies, MD, Wolfgang A. Radtke,

Albert S. Y. Chang, MD, Nicholas G. Smedira, MD, Catherine L

Too High for Transplantation

Outcomes of heart transplantation in children with hypoplastic left heart syndrome previously palliated with the Norwood procedure Bahaaldin Alsoufi,

Does a similar procedure result in similar survival for women and men undergoing isolated coronary artery bypass grafting? Tamer Attia, MD, MSc, Colleen.

Aortic valve replacement: Is valve size important?

Travis J. Wilder, MD, Brian W. McCrindle, MD, Edward J

William G. Williams, MDa, Jan M. Quaegebeur, MDb, John W

Mitral valve operation in patients with the Marfan syndrome

Impact of Patient Characteristics and Anatomy on Results of Norwood Operation for Hypoplastic Left Heart Syndrome Bahaaldin Alsoufi, MD, Makoto Mori,

Reduced survival in women after valve surgery for aortic regurgitationEffect of aortic enlargement and late aortic rupture Monica L. McDonald, MDa, Nicholas.

Biventricular strategies for neonatal critical aortic stenosis: High mortality associated with early reintervention Edward J. Hickey, MD, Christopher.

Nicholas G. Smedira, MD, Katherine J. Hoercher, RN, Dustin Y

Eugene H. Blackstone, MDa,b, Bruce W. Lytle, MDb

Influence of Morphology and Initial Surgical Strategy on Survival of Infants With Tricuspid Atresia Bahaaldin Alsoufi, MD, Brian Schlosser, BS, RDCS,

Surgical management of aortopulmonary window associated with interrupted aortic arch: A Congenital Heart Surgeons Society study Igor E. Konstantinov,

Outcomes of multistage palliation of infants with functional single ventricle and heterotaxy syndrome Bahaaldin Alsoufi, MD, Courtney McCracken, PhD,

Palliation Outcomes of Neonates Born With Single-Ventricle Anomalies Associated With Aortic Arch Obstruction Bahaaldin Alsoufi, MD, Courtney McCracken,

Reintervention After Heller Myotomy for Achalasia: Is It Inevitable?

Lars G. Svensson, MD, PhD, Gregory D

Distal aortic interventions after repair of ascending dissection: The argument for a more aggressive approach Eric E. Roselli, MD, Gabriel Loor, MD,

Value of accelerated multimodality therapy in stage IIIA and IIIB non–small cell lung cancer Malcolm M DeCamp, MD, Thomas W Rice, MD, David J Adelstein,

Two internal thoracic artery grafts are better than one

David P. Mason, MD, Dale H. Marsh, MD, Joan M. Alster, MS, Sudish C

Long-term effectiveness of operations for ascending aortic dissections

Decision support in surgical management of ischemic cardiomyopathy

Impact of Anastomotic Airway Complications After Lung Transplantation

Bahaaldin Alsoufi, MD, Cedric Manlhiot, BSc, Brian W

M1a/M1b esophageal carcinoma: Clinical relevance

Truncus Arteriosus Associated with Interrupted Aortic Arch in 50 Neonates: A Congenital Heart Surgeons Society Study Igor E. Konstantinov, MD, PhD, Tara.

Yuji Tachimori, MD, Hoichi Kato, MD, Hiroshi Watanabe, MD

Mohammed A Quader, MD, Patrick M McCarthy, MD, A

Older children at the time of the Norwood operation have ongoing mortality vulnerability that continues after cavopulmonary connection Bahaaldin Alsoufi,

Is repair preferable to replacement for ischemic mitral regurgitation?

Ventilatory dependency after cardiovascular surgery

Douglas R. Johnston, MD, Edward G

Turki B. Albacker, MD, MSc, Eugene H. Blackstone, MD, Sarah J

Cardiac transplant coronary artery disease: A multivariable analysis of pretransplantation risk factors for disease development and morbid events David.

Age and valve size effect on the long-term durability of the Carpentier-Edwards aortic pericardial bioprosthesis Michael K Banbury, MD, Delos M Cosgrove,

Mitral valve repair with aortic valve replacement is superior to double valve replacement A.Marc Gillinov, MD, Eugene H Blackstone, MD, Delos M Cosgrove,

Siva Raja, MD, PhD, Jay J. Idrees, MD, Eugene H

Arvind K. Agnihotri, MD (by invitation), David C

Pulmonary hypertension is associated with worse early and late outcomes after aortic valve replacement: Implications for transcatheter aortic valve replacement

Outcomes of neonates requiring prolonged stay in the intensive care unit after surgical repair of congenital heart disease Makoto Mori, MD, Courtney.

Identifying risk factors: Challenges of separating signal from noise

Lung Transplantation for Idiopathic Pulmonary Fibrosis

Fernando A. Atik, MD, Lars G. Svensson, MD, PhD, FACC, Eugene H

Presentation transcript:

Intermediate survival in neonates with aortic atresia: A multi-institutional study Marshall L. Jacobs, MD, Eugene H. Blackstone, MD, Leonard L. Bailey, MD The Journal of Thoracic and Cardiovascular Surgery Volume 116, Issue 3, Pages 417-431 (September 1998) DOI: 10.1016/S0022-5223(98)70008-X Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Non-risk-adjusted survival and hazard function for death for all 323 patients in the study. A, Survival after entry (at time zero). Each circle represents an actual death, positioned at the time of death along the horizonal axis and actuarially along the vertical axis. The vertical bars depict ± 1 standard error. The numbers indicate the number of patients remaining at risk at the time of the estimate. The solid line is the parametric estimate of survival, and the dashed lines enclose the 70% confidence intervals. B, Hazard function for death. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Schematic diagram of the treatment pathway and fate of the 323 patients after initial protocol assignment. SVC-PA, Superior vena cava–pulmonary artery. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Non-risk-adjusted survival for patients treated at the 4 low-risk institutions. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Non-risk-adjusted survival and hazard function for patients (n = 253) initially entered in the staged reconstructive surgery protocol. A, Survival after entry (at time zero). B, Hazard function for death. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 5 Competing Risks Analysis for patients in the staged reconstructive surgery protocol (n = 253). The number of patients (expressed as a percent of total) in each of 5 categories across the time of follow-up is depicted. All patients begin alive, awaiting definitive repair. Thereafter, patients migrate to death, the Fontan operation, heart transplantation, and 2-ventricle repair according to the respective hazard functions operating on those remaining alive, awaiting definitive repair. At every point in time, the number of patients in all categories adds to 100% (so-called conservation of patients). Symbols represent each event, positioned on the vertical axis by multiple decrement analysis. The solid curves represent mathematical estimates of the accumulative effect of the 4 hazard functions operating on the original group of patients. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 6 Non-risk-adjusted survival and hazard function for death for patients (n = 49) initially entered in the heart transplant protocol. A, Survival after entry (at time zero). B, Hazard function for death. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 7 Competing Risks Analysis for patients (n = 49) initially entered into the heart transplant protocol. The number of patients (expressed as a percent of total) in each of 4 categories across the time of follow-up is depicted. All patients begin alive, awaiting transplantation. Thereafter, patients migrate to heart transplantation, death awaiting transplantation, and Norwood operations according to the respective hazard function. The depiction is otherwise as in Fig. 5. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 8 Non-risk-adjusted survival for patients awaiting transplantation in the heart transplantation protocol, and for patients in the no surgical treatment protocol. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 9 Actuarial (life-table) survival of patients stratified according to the 3 treatment protocols. Each symbol represents an actual death, positioned at the time of death along the horizontal axis and actuarially along the vertical axis. The vertical bars depict ± 1 standard error. The numbers indicate the number of patients remaining at risk at the time of estimate. The solid lines are the parametric estimates of survival, and the dashed lines enclose the 70% confidence intervals. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 10 A, Non-risk-adjusted survival of patients entered into treatment protocols at the 4 low-risk institutions. The 70% confidence intervals converge at a point approximately 1 week after entry and continue to overlap thereafter. B, Survival of patients initially entering either surgical treatment protocol at the 4 low-risk institutions is shown, together with results at the remaining institutions. Patients for whom the nonsurgical protocol was initially designated are excluded from this analysis. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 417-431DOI: (10.1016/S0022-5223(98)70008-X) Copyright © 1998 Mosby, Inc. Terms and Conditions