Figure 1 (a) Genetic backbone of pECPB39 (MG886287) and pKP13a (CP003996) plasmids. In pECPB39, the ΔproP-mcr-5.3-chrB ... Figure 1 (a) Genetic backbone.

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Figure 1 (a) Genetic backbone of pECPB39 (MG886287) and pKP13a (CP003996) plasmids. In pECPB39, the ΔproP-mcr-5.3-chrB ... Figure 1 (a) Genetic backbone of pECPB39 (MG886287) and pKP13a (CP003996) plasmids. In pECPB39, the ΔproP-mcr-5.3-chrB array has been incorporated into the pKP13a backbone. In fact, the mcr-5.3 gene is embedded within a Tn3-family transposon with a 38 bp IRL, as previously reported.<sup>3</sup> DUF, domain of unknown function proteins. (b) Comparison of MCR-5-type phosphoethanolamine transferase proteins of S. enterica subsp. enterica serovar Paratyphi B and E. coli strains identified in Germany<sup>3</sup><sup>,</sup><sup>4</sup> and Brazil (this study). The position of the amino acid deletion in MCR-5.2 (Glu233) is indicated by a dash (highlighted in grey), whereas the amino acid substitution in MCR-5.3 (Ala414Ser) is indicated in bold (highlighted in grey). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) J Antimicrob Chemother, Volume 73, Issue 12, 07 September 2018, Pages 3520–3522, https://doi.org/10.1093/jac/dky341 The content of this slide may be subject to copyright: please see the slide notes for details.