Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated.

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Presentation transcript:

Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial Mara Y. Roth, M.D., Kat Lin, M.D., Katrine Bay, M.Sc., Ph.D., John K. Amory, M.D., M.P.H., Bradley D. Anawalt, M.D., Alvin M. Matsumoto, M.D., Brett T. Marck, B.S., William J. Bremner, M.D., Ph.D., Stephanie T. Page, M.D., Ph.D. Fertility and Sterility Volume 99, Issue 1, Pages 132-139 (January 2013) DOI: 10.1016/j.fertnstert.2012.09.009 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Baseline correlation between serum INSL3 and serum LH for all 31 subjects. The line shown represents the best linear fit. Fertility and Sterility 2013 99, 132-139DOI: (10.1016/j.fertnstert.2012.09.009) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Box plot of serum INSL3 concentration in gonadotropin-suppressed subjects at baseline (n = 31) and on day 10 by treatment group (n = 6 for the 0-IU hCG group, n = 7 for the 15-IU hCG group, and n = 5 for the 60-IU hCG group and 125-IU hCG group). *P<.05 compared with baseline, 60-IU hCG group, and 125-IU hCG group. Dotted lines and gray shading represent the normal range for serum INSL3. Fertility and Sterility 2013 99, 132-139DOI: (10.1016/j.fertnstert.2012.09.009) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 3 (A–C) Correlations between posttreatment serum INSL3 for all 23 subjects receiving hCG therapy intratesticular T (A), serum T (B), and serum hCG (C). Dotted lines represent the lower limit of the normal range. Lines shown represent the best linear fit. Fertility and Sterility 2013 99, 132-139DOI: (10.1016/j.fertnstert.2012.09.009) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions