Noninvasive Assessment of Brain Injury in a Canine Model of Hypothermic Circulatory Arrest Using Magnetic Resonance Spectroscopy Christopher J. Barreiro,

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Presentation transcript:

Noninvasive Assessment of Brain Injury in a Canine Model of Hypothermic Circulatory Arrest Using Magnetic Resonance Spectroscopy Christopher J. Barreiro, MD, Jason A. Williams, MD, Torin P. Fitton, MD, Mary S. Lange, MA, Mary E. Blue, PhD, Lisa Kratz, PhD, Peter B. Barker, PhD, Mahaveer Degaonkar, PhD, Vincent L. Gott, MD, Juan C. Troncoso, MD, Michael V. Johnston, MD, William A. Baumgartner, MD The Annals of Thoracic Surgery Volume 81, Issue 5, Pages 1593-1598 (May 2006) DOI: 10.1016/j.athoracsur.2006.01.011 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Clinical neurologic scores using the Pittsburgh canine neurologic scoring system (0 = normal; 500 = brain death). (Dark gray bars = hypothermic circulatory arrest [n = 16]; light gray bars = hypothermic circulatory arrest plus diazoxide [n = 23]; hr = hours.) The Annals of Thoracic Surgery 2006 81, 1593-1598DOI: (10.1016/j.athoracsur.2006.01.011) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Magnetic resonance spectroscopy–measured N-acetyl-asparate:choline (NAA:Cho) ratios for the cortex, cerebellum, and hippocampus. The p values compare normal animals (black bars; n = 15) versus hypothermic circulatory arrest (HCA) animals (dark gray bars; n = 15); *p values compare HCA versus HCA+diazoxide animals (light gray bars; n = 15). (NS = not significant.) The Annals of Thoracic Surgery 2006 81, 1593-1598DOI: (10.1016/j.athoracsur.2006.01.011) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Fresh brain tissue N-acetyl-asparate extraction determined by mass spectrometry for the cortex, cerebellum, and hippocampus. The p values compare normal animals (black bars; n = 15) versus 24-hour hypothermic circulatory arrest (HCA) animals (dark gray bars; n = 15); *p values compare HCA versus 24-hour HCA+diazoxide animals (light gray bars; n = 15). The Annals of Thoracic Surgery 2006 81, 1593-1598DOI: (10.1016/j.athoracsur.2006.01.011) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions