The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure Maria.

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The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure Maria Ruiz-Alonso, M.Sc., David Blesa, Ph.D., Patricia Díaz-Gimeno, Ph.D., Eva Gómez, M.Sc., Manuel Fernández-Sánchez, M.D., Francisco Carranza, M.D., Joan Carrera, M.D., Felip Vilella, Ph.D., Antonio Pellicer, M.D., Ph.D., Carlos Simón, M.D., Ph.D. Fertility and Sterility Volume 100, Issue 3, Pages 818-824 (September 2013) DOI: 10.1016/j.fertnstert.2013.05.004 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Pregnancy and implantation rate per month in which the first pET was done after the ERA biopsy. Fertility and Sterility 2013 100, 818-824DOI: (10.1016/j.fertnstert.2013.05.004) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) Clinical outcome of nonreceptive RIF and comparison group patients that underwent pET. Values are mean ± SD. (B) Principal component analysis (PCA) of three samples from the same patient at P+4, P+5, and P+6, the ERA gene expression training sets (proliferative, pre-receptive, receptive and post-receptive samples) used in the development of the ERA prediction tool (17). The points represent the samples in relation to 238 expressed genes. The three samples from the same patient (at P+4, P+5, and P+6) are represented in red. The samples from the training set are represented in different colors: proliferatives are dark red, pre-receptives are purple, receptives are green, and post-receptives are blue. The study samples P+4 and P+5 show a pre-receptive profile, while the P+6 sample shows a receptive profile. PC1, PC2 = first and second principal components that explain the highest variability that separates samples in the space. Fertility and Sterility 2013 100, 818-824DOI: (10.1016/j.fertnstert.2013.05.004) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Clinical algorithm for pET. Fertility and Sterility 2013 100, 818-824DOI: (10.1016/j.fertnstert.2013.05.004) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions