The incidence and risk factors of invasive fungal infection after haploidentical haematopoietic stem cell transplantation without in vitro T-cell depletion

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Presentation transcript:

The incidence and risk factors of invasive fungal infection after haploidentical haematopoietic stem cell transplantation without in vitro T-cell depletion Y.-Q. Sun, L.-P. Xu, D.-H. Liu, X.-H. Zhang, Y.-H. Chen, H. Chen, Y. Ji, Y. Wang, W. Han, J.-Z. Wang, F.-R. Wang, K.-Y. Liu, X.-J. Huang Clinical Microbiology and Infection Volume 18, Issue 10, Pages 997-1003 (October 2012) DOI: 10.1111/j.1469-0691.2011.03697.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1. The reconstitution of peripheral blood lymphocytes after haploidentical haematopoietic stem cell transplantation. (a) Absolute lymphocyte counts. (b) CD4+ cell numbers. Clinical Microbiology and Infection 2012 18, 997-1003DOI: (10.1111/j.1469-0691.2011.03697.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2. (a) Cumulative incidence of invasive fungal infection (IFI) after haploidentical haematopoietic stem cell transplantation without in vitro T-cell depletion. (b) Cumulative incidence of IFI in patients with 0-1 or 2-3 of the following factors: at high risk for underlying disease, grade III–IV acute graft-versus-host disease, and platelet engraftment time of >17 days. Clinical Microbiology and Infection 2012 18, 997-1003DOI: (10.1111/j.1469-0691.2011.03697.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3. (a) Probability of survival after diagnosis of invasive fungal infection (IFI) in 39 recipients of haematopoietic stem cell transplants from haploidentical donors. (b) The impact of IFI on overall survival. Patients without IFI had significantly better overall survival than patients with IFI (p <0.001). Clinical Microbiology and Infection 2012 18, 997-1003DOI: (10.1111/j.1469-0691.2011.03697.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions