The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing.

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Presentation transcript:

The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing open cardiac surgery: A randomized controlled trial Massimo Caputo, MD, Amir Mokhtari, MRCS, Chris A. Rogers, PhD, Nayia Panayiotou, MSc, Qiang Chen, PhD, Mohamed T. Ghorbel, PhD, Gianni D. Angelini, FRCS, Andrew J. Parry, FRCS The Journal of Thoracic and Cardiovascular Surgery Volume 138, Issue 1, Pages 206-214 (July 2009) DOI: 10.1016/j.jtcvs.2008.12.028 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Time-related plasma changes in the geometric mean troponin I in the hyperoxic (•) and normoxic (▪) groups. B, Time-related plasma changes in the geometric mean 8-isoprostane in the hyperoxic (•) and normoxic (▪) groups. CPB, Cardiopulmonary bypass; SE, standard error. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 206-214DOI: (10.1016/j.jtcvs.2008.12.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A, Time-related plasma changes in the geometric mean protein S100 in the hyperoxic (•) and normoxic (▪) groups. B, Time-related plasma changes in the geometric mean alpha-glutathione S-transferase (άGT) in the hyperoxic (•) and normoxic (▪) groups. CPB, Cardiopulmonary bypass; SE, standard error. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 206-214DOI: (10.1016/j.jtcvs.2008.12.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 A, Time-related plasma changes in the geometric mean interleukin 6 (IL-6) in the hyperoxic (•) and normoxic (▪) groups. B, Time-related plasma changes in the geometric mean interleukin 8 (IL-8) in the hyperoxic (•) and normoxic (▪) groups. CPB, Cardiopulmonary bypass; SE, standard error. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 206-214DOI: (10.1016/j.jtcvs.2008.12.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 A, Time-related plasma changes in the geometric mean interleukin 10 (IL-10) in the hyperoxic (•) and normoxic (▪) groups. B, Time-related plasma changes in the geometric mean C3a in the hyperoxic (•) and normoxic (▪) groups. CPB, Cardiopulmonary bypass; SE, standard error. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 206-214DOI: (10.1016/j.jtcvs.2008.12.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Time-related plasma changes in the geometric mean cortisol in the hyperoxic (•) and normoxic (▪) groups. CPB, Cardiopulmonary bypass; SE, standard error. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 206-214DOI: (10.1016/j.jtcvs.2008.12.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions