Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery Kuang-Yu Liu, PhD, Jochen.

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Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery Kuang-Yu Liu, PhD, Jochen D. Muehlschlegel, MD, Tjörvi E. Perry, MD, Amanda A. Fox, MD, Charles D. Collard, MD, Simon C. Body, MBChB, MPH, Stanton K. Shernan, MD The Journal of Thoracic and Cardiovascular Surgery Volume 139, Issue 2, Pages 483-488.e2 (February 2010) DOI: 10.1016/j.jtcvs.2009.06.032 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Cardiac troponin I level for 9p21 risk allele. The SNP rs10116277 plotted against cardiac troponin I values on the 7 perioperative time points. The bars on an individual day represent the copies of the risk allele; the first bar represents two copies, the second bar one copy, and the third bar no copy of the risk allele. Each bar represents median with interquartile range and outliers are shown by the dotted lines. ∗P < .01. cTnI, Cardiac troponin I; Pre, preoperatively; Post, immediately after protamine. The Journal of Thoracic and Cardiovascular Surgery 2010 139, 483-488.e2DOI: (10.1016/j.jtcvs.2009.06.032) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Linkage-disequilibrium (LD) plot of 9p21 region. The upper panel shows negative log10P values for the association of the individual single nucleotide polymorphism (SNPs) at their physical location with perioperative myocardial injury (PMI), after adjustment in multivariable regression model. The lower panel summarizes the LD structure in the HapMap database (CEU European ancestry). Regions of LD are shaded in gray (moderate LD) or black (strong LD). Predicted haplotype blocks are framed by triangles. The physical location of the genes CDKN2A, CDKN2B, and ANRIL are shown in the HapMap info tack above the SNPs. The type 2 diabetes locus is seen on the far right side of the LD plot, with a nonsignificant association with PMI. CDKN, Cyclin-dependent kinase; ANRIL, antisense noncoding RNA gene; T2D, type 2 diabetes. The Journal of Thoracic and Cardiovascular Surgery 2010 139, 483-488.e2DOI: (10.1016/j.jtcvs.2009.06.032) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions