IMACS First Annual Report Appendix 1. IMACS – Participating Hospitals (n = 17, Coverage: 1/9/2013-12/31/2014). City Country Hospital Perth Australia Western Fiona Stanley Hospital Sydney Australia St. Vincent’s Hospital Fortaleza Brazil Hospital de Messejana Athens Greece Evaggelismos Medical Center Dublin Ireland Mater Misericordiae University Hospital Tel HaShomer Israel Sheba Medical Center Udine Italy Azienda Ospedaliero Universitaria Santa Maria Della Misericordia Milan Niguarda Ca’Granda Hospital Auckland New Zealand Auckland Hospital Riyadh Saudi Arabia King Faisal Specialist Hospital & Research Centre Singapore National Heart Centre Singapore Bratislava Slovakia National Institute of Cardiovascular Diseases A Coruña Spain Complexo Hospitalario Universitario a Coruna Madrid Hospital Universitario Puerto de Hierro Stockholm Sweden Karolinska University Hospital Scania Skane University Hospital Linköping University Hospital Linkoping 10/20/2015 IMACS First Annual Report

Appendix 2. IMACS – Information Collected Data Collected Pre-Implant Implant 1 week/ 1 month Discharge 3 months/ every 6 months Demographics X   Medical Support Status Comorbidities Hemodynamics Medications Laboratory Medical Condition Exercise Function Patient Status Device information Device details Device parameters Adverse Event Reminders Chronology of Hospital Time 10/20/2015 IMACS First Annual Report

Appendix 3. Potential Covariates used in Multivariable Model Demographics Age, Male, White, College, Married, Body Mass Index , Body Surface Area, Ethnicity Patient Profile Levels NYHA 4 Comorbidities Previous Cancer, Ascites, Diabetes, Smoker, Alcohol Abuse, Cardiovascular accident (CVA), Peripheral vascular disease (PVD), Carotid artery disease, Diagnosis – coronary artery disease, History of CABG, History of Valve surgery, ICD Implant Information Concomitant surgery, Continuous flow device, Bi-ventricular placement, Failure to wean, Post cardiac operation Pre-Implant Laboratory Values Cholesterol, INR, Sodium, Albumin, Total Bilirubi,n SGOT/AST, White blood cell (WBC), Blood urea nitrogen (BUN), Creatinine, Pre-albumin Device Strategy @ Implant Destination Therapy Pre-Implant Interventions Ventilator, IABP, Inotropes, Dialysis Hemodynamics (Pre-Implant) Systolic blood pressure, Diastolic book pressure, Right atrial pressure, Cardiac Output, Cardiac Index, LVEDD%, Pulmonary Wedge pressure, Pulmonary diastolic pressure, Pulmonary systolic pressure, PVR-Cardiac Index, PVR-Cardiac Output, LVEF < 20, Severe RVEF 10/20/2015 IMACS First Annual Report