Endothelium-dependent contraction of canine coronary artery is enhanced by crystalloid cardioplegic solution Pyng Jing Lin, MD, Chau-Hsiung Chang, MD,

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Endothelium-dependent contraction of canine coronary artery is enhanced by crystalloid cardioplegic solution Pyng Jing Lin, MD, Chau-Hsiung Chang, MD, Pei-Chin Yao, BS, Hui-Ping Liu, MD, Hung-Chang Hsieh, MD, Kuei-Ton Tsai, MD The Journal of Thoracic and Cardiovascular Surgery Volume 109, Issue 1, Pages 99-105 (January 1995) DOI: 10.1016/S0022-5223(95)70425-6 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Isometric tension recordings of the effect of cardioplegic solution on endothelium-dependent responses to hypoxia. Canine coronary arterial segments were preserved with crystalloid cardioplegic solution (group 1) and physiologic solution (group 2) at 4° C for 60 minutes. The preserved (group 1 to 2) and control (group 3) coronary segments were then suspended in an organ chamber gassed with 95% oxygen and 5% carbon dioxide (Po2 405 ± 15 mm Hg) and contracted with prostaglandin F2α (2 x 10 -6 mol/L). When the contractile response to prostaglandin F2α was stable, hypoxia was induced by changing to a 95% nitrogen/5% carbon dioxide (Po2 35 ± 5 mm Hg) gas mix. After 20 minutes, oxygenation was reintroduced. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 99-105DOI: (10.1016/S0022-5223(95)70425-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of hypoxia (95% nitrogen/5% carbon dioxide) on tension in contracted (by prostaglandin F2α 2 × 10 -6 mol/L) canine coronary arterial segments with endothelium of all three groups. Data are shown as means ± standard error of the mean and are expressed as percent change from the initial contraction to prostaglandin F2α (zero on y axis). *Significant difference from segments with endothelium of other groups. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 99-105DOI: (10.1016/S0022-5223(95)70425-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Effect of hypoxia and drugs on tension in contracted (by prostaglandin F2α 2 × 10-6 mol/L) canine coronary arterial segments with endothelium of all three groups. Data are shown as means ± standard error of the mean and expressed as percent of the initial contraction to prostaglandin F2α. *Significant difference from control untreated segments (group 3) with endothelium (p < 0.02). #Significant difference from untreated segments with endothelium in the same group (p < 0.05). l -NMMA, NG -monomethyl-l-arginine. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 99-105DOI: (10.1016/S0022-5223(95)70425-6) Copyright © 1995 Mosby, Inc. Terms and Conditions