Volume 39, Issue 6, Pages (December 2003)

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Volume 39, Issue 6, Pages 1004-1012 (December 2003) Molecular features of non-B, non-C hepatocellular carcinoma: a PCR-array gene expression profiling study Yukinori Kurokawa, Ryo Matoba, Ichiro Takemasa, Shoji Nakamori, Masanori Tsujie, Hiroaki Nagano, Keizo Dono, Koji Umeshita, Masato Sakon, Noriko Ueno, Hiroko Kita, Shigeyuki Oba, Shin Ishii, Kikuya Kato, Morito Monden Journal of Hepatology Volume 39, Issue 6, Pages 1004-1012 (December 2003) DOI: 10.1016/S0168-8278(03)00473-2

Fig. 1 Hierarchical clustering of 1812 genes in 68 non-B, non-C liver samples (20 HCC, 17 non-tumor, and 31 normal). Each column represents a single gene, while each row represents a patient sample. The tissue type of each sample is designated by a right bar, with red, yellow, and green bars indicating HCC, non-tumor and normal liver samples, respectively. The color scale at the bottom indicates the relative expression levels in terms of standard deviations from the mean. Journal of Hepatology 2003 39, 1004-1012DOI: (10.1016/S0168-8278(03)00473-2)

Fig. 2 (A) The expression pattern of the 61 genes differentially expressed between HCC and non-tumor liver. (B) The expression pattern of 159 genes differentially expressed between non-tumor and normal liver. Each column represents a patient sample, while each row represents a single gene. All genes are rearranged according to ranking by signal-to-noise ratio, and only a few selected gene names are shown due to limited space. Journal of Hepatology 2003 39, 1004-1012DOI: (10.1016/S0168-8278(03)00473-2)

Fig. 3 Expression levels of 12 cancer-related genes in non-B, non-C HCC (T), non-tumor liver (NT), and normal liver (N). The averages and standard errors of relative expression levels of p53, p73, RB1, cyclin D1, M6P/IGF2R, PTEN, IGFBP3, beta-catenin, K-ras, c-myc, c-fos, and p21 are shown. P values were calculated by t test. Journal of Hepatology 2003 39, 1004-1012DOI: (10.1016/S0168-8278(03)00473-2)