Meta-analysis: is moving the goal post the answer?

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Presentation transcript:

Meta-analysis: is moving the goal post the answer? Matthias Egger, George Davey Smith, Jonathan AC Sterne  The Lancet  Volume 351, Issue 9114, (May 1998) DOI: 10.1016/S0140-6736(05)78914-5 Copyright © 1998 Elsevier Ltd Terms and Conditions

Cumulative meta-analysis of trials of intravenous magnesium for suspected myocardial infarction, with stopping boundaries (2α=0·01) Analysis of ten selected trials reported by Pogue and Yusuf1 (upper panel)and re-analysis with all 15 trials (lower panel). Trial 11 is ISIS-4. References 1–16 available from authors. The Lancet 1998 351, DOI: (10.1016/S0140-6736(05)78914-5) Copyright © 1998 Elsevier Ltd Terms and Conditions

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